Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Bram Kuijper, Mark A. Hanson, Emma I.K. Vitikainen, Harry H. Marshall, Susan E. Ozanne & Michael A. Cant,
2019, Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1770), 1-7
Type: letterEditorial
Peter D. Gluckman, Mark A. Hanson & Felicia M. Low,
2019, Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1770), 1-8
Type: review
Jun S. Lai, Soh E. Soh, See Ling Loy, Marjorelee T. Colega, Michael S. Kramer, Jerry K.Y. Chan, Thiam Chye Tan, Lynette P.C. Shek, Fabian Yap, Kok Hian Tan, Keith Godfrey, Yap-Seng Chong & Mary F.F. Chong,
2019, European Journal of Nutrition, 58(3), 1081-1094
Type: article
Linda van Lee, Sarah Crozier, Izzuddin M. Aris, Tint Mya, Suresh Sadananthan, Navin Michael, Phaik Ling Quah, Sian M Robinson, Hazel Inskip, Nicholas Harvey, Mary Barker, Cyrus Cooper, Sendhil Velan, Yung Seng Lee, Marielle V. Fortier, Fabian Yap, Peter D. Gluckman, Kok Hian Tan, Lynette Pei-Chi Shek , Yap-Seng Chong, Keith Godfrey & Mary F.F. Chong,
2019, International Journal of Epidemiology, 48(2), 433-444
DOI: 10.1093/ije/dyy291
Type: article
Oliver C. Watkins, Mohammad Omedul Islam, Preben Selvam, Reshma Appukuttan Pillai, Amaury Cazenave-Gassiot, Anne K. Bendt, Neerja Karnani, Keith M. Godfrey, Rohan M. Lewis, Markus R. Wenk & Shiao-Yng Chan,
2019, Endocrinology
Type: article
Jonathan Y. Bernard, Sharon Ng, Natarajan Padmapriya, See Ling Loy, Izzudin M. Aris, Tint Mya, Yap-Seng Chong, Lynette Shek, Jerry Kok Yen Chan, Keith Godfrey, Chin Meng Khoo, Melvin Khee-Shing Leow, Falk Müller-Riemenschneider & Shiao-Yng Chan,
2019, Diabetic Medicine
DOI: 10.1111/dme.13948
Type: article
Agnethe Lund, Cathrine Ebbing, Svein Rasmussen, Torvid Kiserud, Mark Hanson & Jörg Kessler,
2019, PLoS ONE, 14(3)
Type: article