Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Chandni Maria Jacob, Marie-Louise Newell & Mark Hanson,
2019, Obesity Reviews, 20(S1), 5-17
DOI: 10.1111/obr.12769
Type: review
Tinu M. Samuel, Olga Sakwinska, Kimmo Makinen, Graham C. Burdge, Keith M. Godfrey & Irma Silva Zolezzi,
2019, Nutrients, 11(8), 1-26
DOI: 10.3390/nu11081811
Type: article
Sam Wilding, Nida Ziauddeen, Paul Roderick, Dianna Smith, Debbie Chase, Nicholas Macklon, Nuala Mcgrath, Mark Hanson & Nisreen Alwan,
2019, BMJ Open, 9(7)
Type: article
Susana G. Santos, Ellis Voerman, Pilar Amiano, Henrique Barros, Lawrence J Beilin, Anna Bergström, Marie-Aline Charles, Leda Chatzi, Cecile Chevrier, George P. Chrousos, Eva Corpeleijn, Olga Costa, Nathalie Costet, Sarah Crozier, Graham Devereux, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Vagelis Georgiu, Keith Godfrey, Davide Gori, Veit Grote, Wojciech Hanke, Irva Hertz-Picciotto, Barbara Heude, Marie-France Hivert, Daniel O. Hryhorczuk, Rae-Chi Huang, Hazel Inskip, Anne M. Karvonen, Louise C. Kenny, Berthold Koletzko, Leanne K. Küpers, Hanna Lagstrom, Irina Lehmann, Per Magnus, Renata Majewska, Johanna Makela, Yannis Manios, Fionnuala M. McAuliffe, Sheila W. McDonald, John Mehegan, Erik Melén, Monique Mommers, Camilla S Morgen, George Moschonis, Deirdre Murray, Carol Ni Chaoimh, Ellen Aagaard Nohr, Anne-Marie Nybo Andersen, Emily Oken, Adriette J J M. Oostvogels, Agnieszka Pac, Eleni Papadopoulou, Juha Pekkanen, Costanza Pizzi, Kinga Polanska, Daniela Porta, Lorenzo Richiardi, Sheryl L. Rifas-shiman, Nel Roeleveld, Luca Ronfani, Ana C. Santos, Marie Standl, Hein Stigum, Camilla Stoltenberg, Elisabeth Thiering, Carel Thijs, Maties Torrent, Suzanne C. Tough, Tomas Trnovec, Steve Turner, Marleen M. H. J. van Gelder, Lenie van Rossem, Andrea von Berg, Martine Vrijheid, Tanja G. M. Vrijkotte & Jane West,
2019, BJOG: An International Journal of Obstetrics & Gynaecology, 126(8), 984-995
Type: article
Kathryn Dalrymple, Shahina Begum, John M.D. Thompson, Wayne Cutfield, Ying Huang, Paul T. Seed, Andrew N. Shelling, Clare R. Wall, Robyn North, Lesley M.E. McCowan, Lucilla Poston, Keith Godfrey & Edwin A. Mitchell,
2019, Pediatric Obesity
DOI: 10.1111/ijpo.12537
Type: article
Mark Hanson, Christina Vogel, Kathryn Woods-Townsend, Keith Godfrey & Mary Barker,
2019, The Lancet, 393(10187), 2262-2271
Type: article
M. A. Hanson, L. Poston & P. D. Gluckman,
2019, Journal of Developmental Origins of Health and Disease, 10(3), 263-267
Type: letterEditorial