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J Nicoll art/pg2006/4

Staff

Other researchers

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

  • Delphine serves on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.
  • Her main research interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the approaches of human brain analysis. Her research focuses on microglia, the immune cells of the brain, where she has developed protocols to immunophenotype microglia in humans using markers relating to a specific function allowing us to investigate the role of these cells in different neurological conditions.
  • Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed an expertise in neuroimmunopathology

Emeritus Professor Clive Holmes

Collaborating research institutes, centres and groups

Clinical Neurosciences

Examining how clinical and environmental factors can affect brain development.

Research outputs

Histopathological correlates of hemorrhagic lesions on ex vivo MRI in immunized Alzheimer’s disease cases.
Ashley Scherlek,
Mariel Kozberg,
James Nicoll,
Valentina Perosa,
Whitney Freeze,
Louise van der Weerd,
Brian Bacskai,
Steven Greenberg,
Matthew Frosch,
Delphine Boche,
& Susanne van Veluw
, 2022 , Brain Communications
Type: article
Understanding cause and effect in Alzheimer's pathophysiology: implications for clinical trials
Delphine Boche,
& James Nicoll
, 2020 , Neuropathology and Applied Neurobiology
Type: review
Persistent neuropathological effects 14 years following amyloid-β immunisation in Alzheimer’s disease
James A.R. Nicoll,
George R. Buckland,
Charlotte H. Harrison,
Anton Page,
Scott Harris,
Seth Love,
James W. Neal,
Clive Holmes,
& Delphine Boche
, 2019 , Brain , 142 (7) , 2113--2126
DOI: 10.1093/brain/awz142
Type: article
Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study
Diana, Karina Franco Bocanegra,
Bethany George,
Laurie C. Lau,
Clive Holmes,
James A.R. Nicoll,
& Delphine Boche
, 2019 , Acta Neuropathologica Communications , 7 (1) , 174
DOI: 10.1186/s40478-019-0828-x
Type: article
Brief communication. A novel method to visualise the three-dimensional organisation of the human cerebral cortical vasculature
C H Harrison,
G R Buckland,
S E Brooks,
D A Johnston,
D S Chatelet,
A K L Liu,
S M Gentleman,
D Boche,
& J A R Nicoll
, 2018 , Journal of Anatomy , 1--6
DOI: 10.1111/joa.12805
Type: article
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