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Professor Delphine Boche

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

  • Neuroimmunology and neurodegeneration
  • Immunophenotyping immune cells
  • Human brain pathology

More research

Connect with Delphine

Email: D.Boche@soton.ac.uk

Tel: +44 23 8059 2219

Google Scholar
ORCID
Research Publications Teaching External roles and responsibilities Biography
Research Publications Teaching External roles and responsibilities Biography

Research

Research groups

Research interests

  • Neuroimmunology and neurodegeneration
  • Immunophenotyping immune cells
  • Human brain pathology
  • Ageing and systemic inflammation

Current research

Delphine serves as PI and Co-PI on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.  Her current projects include:

  • Immunophenotyping microglia in neurological conditions such as Alzheimer's disease, dementia with lew bodies, schizophrenia, glioblastoma
  • Neuroinflammation in age-related dementia
  • Exploring the impact of systemic inflammation on microglial phenotype and brain pathology
  • Aβ immunotherapy in human Alzheimer's disease

Research projects

Active projects

Continued Brain Tumour Research Funding For BRAIN UK (2022 - 2025)
Sponsor: Brain Tumour Research
Study of immune reactions and correlation of imaging findings in CAA-related inflammation
Sponsor: The Pathological Society of Great Britain & Ireland
Investigating spontaneous CAA-related inflammation as a model for Aβ immunotherapy-induced side effects (ARIA)
T-cell Response in Cerebral Amyloid Angiopathy- Related Inflammation

Completed projects

Microglial motility in Alzheimer’s disease
Immunization with amyloid beta-peptide (Abeta) as a novel treatment for Alzheimer’s disease (AD)
Sponsor: Medical Research Council
Epidemiological neuropathology of dementia - The Cognitive Function and Ageing Neuropathology Study: Microglial studies in the CFAS cohort
Sponsor: Medical Research Council
Boche - British Neuropathological Society - Microglia/macrophage immunophenotype in glioblastoma (Mar 18)
Sponsor: British Neuropathological Society
Boche - ARUK - 3D imaging for Life Sciences - (April 18)
Sponsor: Alzheimers Research UK
D Boche: High throughput and high resolution digital slide scanner Nanozoomer
Sponsor: Alzheimers Research UK
D Boche ARUK Network 2012-14
Sponsor: Alzheimers Research UK
The role of inflammation, cerebral hypoperfusion, and pericyte function in dementia
Sponsor: Alzheimers Research UK
Boche - Pathological Society - Tissue-infiltrating lymphocytes characterisation in glioblastoma - (March 18)
Sponsor: The Pathological Society of Great Britain & Ireland
D Boche ARUK - Impact of Systemic Inflammation due to infection on Microglia Phenotype
Sponsor: Alzheimers Research UK
D Boche ART PhD Scholarship brain metaflammasome in neurodegeneration
Sponsor: Alzheimers Research UK
AlzProtAgeing- EU MC IEF - M Moro
Sponsor: European Union
D Boche: J Amin Fellowship, Systemic and central inflammation in dementia with Lewy Bodies
Sponsor: Alzheimers Research UK
Interplay between T cell immunity and innate neuroinflammation ain primary Tauopathies
Sponsor: Alzheimers Research UK
Boche - ARUK - Locus coeruleus: its role in cortical and subcortical inflammation in Alzheimer's disease
Sponsor: Alzheimers Research UK
Developing haptoglobin as a novel intracranial therapeutic
Markers of periodontitis in CSF
Sponsor: Cortexym
J Nicoll art/pg2006/4
Sponsor: Alzheimers Research UK
Confocal laser scanning microscope for dementia researchers
An open-access Spatial Biology Platform for inter-disciplinary studies of human disease    
Sponsor: Medical Research Council
The role of inflammation, cerebral
Characterisation of inflammation contributing to Alzheimer's disease progression
Consequences of active Aβ immunotherapy on the stress and neuronal pathways
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