Professor Delphine Boche

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

Delphine serves on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.
Her main research interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the approaches of human brain analysis. Her research focuses on microglia, the immune cells of the brain, where she has developed protocols to immunophenotype microglia in humans using markers relating to a specific function allowing us to investigate the role of these cells in different neurological conditions.
Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed an expertise in neuroimmunopathology

Email: d.boche@soton.ac.uk

Address: Southampton General Hospital, Tremona Road Shirley, SO16 6YD (View in Google Maps)

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Research

Research groups

Member of:

Research interests

Delphine serves on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.
Her main research interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the approaches of human brain analysis. Her research focuses on microglia, the immune cells of the brain, where she has developed protocols to immunophenotype microglia in humans using markers relating to a specific function allowing us to investigate the role of these cells in different neurological conditions.
Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed an expertise in neuroimmunopathology

Current research

Delphine serves as PI and Co-PI on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration. Her current projects include:

Immunophenotyping microglia in neurological conditions such as Alzheimer's disease, dementia with lew bodies, schizophrenia, glioblastoma
Neuroinflammation in age-related dementia
Exploring the impact of systemic inflammation on microglial phenotype and brain pathology
Aβ immunotherapy in human Alzheimer's disease

Research projects

Active projects

Continued Brain Tumour Research Funding For BRAIN UK (2022 - 2025)

Researchers:

Professor Delphine Boche

Sponsor: Brain Tumour Research

An open-access Spatial Biology Platform for inter-disciplinary studies of human disease

Researchers:

Professor Mark Jones

,

Professor Delphine Boche ,

Professor Rohan Lewis ,

Professor Jane Lucas ,

Doctor Claire Jackson ,

Doctor David Johnston ,

Professor Tom Wilkinson ,

Professor Gareth Thomas ,

Professor Diego Gomez-Nicola ,

Professor Paul Elkington ,

Doctor Matthew Loxham ,

Doctor Jay Amin ,

Doctor Joseph Bell ,

Doctor Zoë Walters ,

Doctor Owen Rackham

Sponsor: Medical Research Council

Completed projects

Microglial motility in Alzheimer’s disease

Researchers:

Professor Delphine Boche

Immunization with amyloid beta-peptide (Abeta) as a novel treatment for Alzheimer’s disease (AD)

Researchers:

Professor Delphine Boche

Sponsor: Medical Research Council

Epidemiological neuropathology of dementia - The Cognitive Function and Ageing Neuropathology Study: Microglial studies in the CFAS cohort

Researchers:

Professor Delphine Boche

Sponsor: Medical Research Council

Boche - British Neuropathological Society - Microglia/macrophage immunophenotype in glioblastoma (Mar 18)

Researchers:

Professor Delphine Boche

Sponsor: British Neuropathological Society

Boche - ARUK - 3D imaging for Life Sciences - (April 18)

Researchers:

Professor Delphine Boche

,

Professor Roxi Carare ,

Doctor Felino Cagampang ,

Doctor Arjuna Ratnayaka ,

Doctor Sandrine Willaime-Morawek

Sponsor: Alzheimers Research UK

D Boche: High throughput and high resolution digital slide scanner Nanozoomer

Researchers:

Professor Delphine Boche

Sponsor: Alzheimers Research UK

D Boche ARUK Network 2012-14

Researchers:

Professor Delphine Boche

Sponsor: Alzheimers Research UK

The role of inflammation, cerebral hypoperfusion, and pericyte function in dementia

Researchers:

Professor Delphine Boche

Sponsor: Alzheimers Research UK

Boche - Pathological Society - Tissue-infiltrating lymphocytes characterisation in glioblastoma - (March 18)

Researchers:

Professor Delphine Boche

Sponsor: The Pathological Society of Great Britain & Ireland

D Boche ARUK - Impact of Systemic Inflammation due to infection on Microglia Phenotype

Researchers:

Professor Delphine Boche

,

Emeritus Professor Clive Holmes

Sponsor: Alzheimers Research UK

D Boche ART PhD Scholarship brain metaflammasome in neurodegeneration

Researchers:

Professor Delphine Boche

Sponsor: Alzheimers Research UK

AlzProtAgeing- EU MC IEF - M Moro

Researchers:

Professor Delphine Boche

Sponsor: European Union

D Boche: J Amin Fellowship, Systemic and central inflammation in dementia with Lewy Bodies

Researchers:

Professor Delphine Boche

,

Emeritus Professor Clive Holmes

Sponsor: Alzheimers Research UK

Interplay between T cell immunity and innate neuroinflammation ain primary Tauopathies

Researchers:

Professor Delphine Boche

Sponsor: Alzheimers Research UK

Boche - ARUK - Locus coeruleus: its role in cortical and subcortical inflammation in Alzheimer's disease

Researchers:

Professor Delphine Boche

,

Emeritus Professor Clive Holmes

Sponsor: Alzheimers Research UK

Developing haptoglobin as a novel intracranial therapeutic

Researchers:

Professor Ian Galea

,

Professor Delphine Boche

Markers of periodontitis in CSF

Researchers:

Professor Jessica Teeling

,

Professor Delphine Boche

Sponsor: Cortexym

J Nicoll art/pg2006/4

Researchers:

Professor Delphine Boche ,

Emeritus Professor Clive Holmes

Sponsor: Alzheimers Research UK

Confocal laser scanning microscope for dementia researchers

Researchers:

Professor Roxi Carare

,

Professor Delphine Boche ,

Professor Andrew Lotery ,

Doctor Arjuna Ratnayaka ,

Doctor David Johnston ,

Professor Amritpal Mudher

External roles and responsibilities

Name: Neuropathology and Applied Neurobiology (Journal)

Role: Member of editorial board

Year: 2015 -

Name: La Caixa Foundation (External organisation)

Role: Member

Year: 2020 -

Name: The Royal Society (External organisation)

Role: Member

Year: 2021 -

Name: Agence Nationale de la Recherche (External organisation)

Role: Member

Year: 2021 -

Name: Research Foundation of Flanders (FWO) (External organisation)

Role: Member

Year: 2021 -

Name: Alzheimer's Research UK (External organisation)

Role: Member

Year: 2016 -

Name: BRAIN UK (External organisation)

Role: Chair

Year: 2022 -

Name: Alzheimer's Association (External organisation)

Role: Chair

Year: 2020 - 2023

Name: Alzheimer's Research & Therapy (Journal)

Role: Editor in chief

Year: 2023

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