Professor Delphine Boche

Research groups

Research interests

• Delphine serves on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.
• Her main research interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the approaches of human brain analysis. Her research focuses on microglia, the immune cells of the brain, where she has developed protocols to immunophenotype microglia in humans using markers relating to a specific function allowing us to investigate the role of these cells in different neurological conditions.
• Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed an expertise in neuroimmunopathology

Current research

Delphine serves as PI and Co-PI on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.  Her current projects include:

• Immunophenotyping microglia in neurological conditions such as Alzheimer's disease, dementia with lew bodies, schizophrenia, glioblastoma
• Neuroinflammation in age-related dementia
• Exploring the impact of systemic inflammation on microglial phenotype and brain pathology
• Aβ immunotherapy in human Alzheimer's disease

Research projects