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Research project

Laser-based engineering (Lab-flo)

Project overview

In 2013 we started work on an 18-month EPSRC feasibility grant entitled 'Laser-printable point-of-care sensors for low-cost medical diagnosis and disease monitoring', which explored laser-based printing of biological materials for applications in the healthcare sector. Our results have attracted the attention of several major international healthcare manufacturers who see the potential of laser-patterning of porous materials like paper for their future product range and who want to work with us to further develop this technology. We are submitting this follow-on proposal to (1) develop a laboratory-standard process for laser-based paper-patterning for fluidic devices, (2) use our technology in trials for a point-of-care diagnostics demonstrator sensor that allows detection of specific diseases such as tuberculosis, as well as dramatically reducing detection limits, (3) extend the technique to incorporate methodologies for fluid delay, multiplexing, and patterning of 3-D devices, and (4) explore applications beyond planar devices in paper, including 'Light-Up Paper' and functionalised fabrics for 'Smart Plasters'.

Staff

Other researchers

Dr Collin Sones

Principal Research Fellow
Connect with Collin

Email: cls@orc.soton.ac.uk

Professor Paul Elkington

Director of Inst. for Medical Innovation
Research interests
  • tuberculosis
  • immunopathology
  • diagnosis
Connect with Paul

Email: P.Elkington@soton.ac.uk

Professor Tony Williams

Professor of Translational Medicine
Connect with Tony

Email: A.P.Williams@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Optimization of flow path parameters for enhanced sensitivity lateral flow devices
Alice Iles, Peijun He, Ioannis Katis, Peter Horak, R.W. Eason & Collin Sones, 2022, Talanta, 248
DOI: 10.1016/j.talanta.2022.123579
Type: article
Laser-patterned paper-based flow-through filters and lateral flow immunoassays to enable the detection of C-reactive protein
Panagiotis Galanis, Ioannis Katis, Peijun He, Alice Iles, Anto J.U. Kumar, R.W. Eason & Collin Sones, 2022, Talanta, 238
DOI: 10.1016/j.talanta.2021.123056
Type: article
Semi-quantitative detection of inflammatory biomarkers using a laser-patterned multiplexed lateral flow device
Alice H. Iles, Peijun J.W. He, Ioannis N. Katis, Panagiotis P. Galanis, Anto J.U.K. John, Paul Elkington, Robert W. Eason & Collin L. Sones, 2022, Talanta, 237, 1-8
DOI: 10.1016/j.talanta.2021.122944
Type: article
Capillary-based reverse transcriptase loop-mediated isothermal amplification for cost-effective and rapid point-of-care COVID-19 testing
Anto John, Peijun He, Ioannis Katis, Panagiotis Galanis, Alice Iles, R.W. Eason & Collin Sones, 2021, Analytica Chimica Acta, 1185
DOI: 10.1016/j.aca.2021.339002
Type: article
Local photo-polymer deposition-assisted fabrication of multilayer paper-based devices
Panagiotis Galanis, Peijun He, Ioannis Katis, Alice Iles, Anto J.U. Kumar, R.W. Eason & Collin Sones, 2020, Sensors and Actuators, B: Chemical, 322
DOI: 10.1016/j.snb.2020.128574
Type: article
Laser-patterned paper-based sensors for rapid point-of-care detection and antibiotic-resistance testing of bacterial infections
Peijun J.W. He, Ioannis N. Katis, Anto J.U. Kumar, Catherine A. Bryant, Charles W. Keevil, Bhaskar K. Somani, Nitin Mahobia, Robert W. Eason & Collin L. Sones, 2020, Biosensors & Bioelectronics, 152
DOI: 10.1016/j.bios.2020.112008
Type: article
Laser-direct-writing to enable filtration in paper-based devices
Panagiotis P. Galanis, Peijun J.W. He, Ioannis N. Katis, Michael R. Thomas, Yunlei Xianyu, Molly M. Stevens, Robert W. Eason & Collin L. Sones, 2019
DOI: 10.1117/12.2508753
Type: conference