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Research project

NIHR Southampton Biomedical Research Centre 2017-2022


Lead researcher

Professor Robert Read

Chair of Infectious Diseases
Other researchers

Professor Chris Byrne

Professor of Endocrinol & Met

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology

Research interests

  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hip fracture in late adulthood
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone mineral accrual in childhood

Professor Philip Calder

Head of School

Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 
  • Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.

Professor Keith Godfrey

Associate Dean Enterprise

Professor Hasan Arshad

Prof in Allergy & Clinical Immunology

Dr Stephen Wootton PhD FAfN OBE

Associate Professor

Professor Graham Roberts

Prof in Paed. Allergy & Resp. Medicine

Professor Saul Faust MBBS, FRCPCH, PhD, FHEA, OBE

Professor Paediatric Immunology & Infect

Research outputs

Raja Dhar,
John Kirkpatrick,
Laura Gilbert,
Arjun Khanna,
Mahavir Madhavdas Modi,
Rakesh K Chawla,
Sonia Dalal,
Venkata Nagarjuna Maturu,
Marcel Stern,
Oliver T Keppler,
Ratko Djukanovic,
& Stephan D Gadola
, 2023 , PLoS ONE , 18 (1) , e0280745
Type: article
Aneurin Young,
R. Mark Beattie,
& Mark John Johnson
, 2023 , Archives of Disease in Childhood - Fetal and Neonatal Edition , 108 (1) , F2--F9
Type: review
Seth Toback,
Eva Galiza,
Catherine Cosgrove,
James Galloway,
Anna L. Goodman,
Pauline A. Swift,
Sankarasubramanian Rajaram,
Alison Graves-Jones,
Jonathan Edelman,
Fiona Burns,
Angela M. Minassian,
Iksung Cho,
Lakshmi Kumar,
Joyce S. Plested,
E. Joy Rivers,
Andreana Robertson,
Filip Dubovsky,
Greg Glenn,
Paul T. Heath,
& Saul N. Faust
, 2022 , The Lancet Respiratory Medicine , 10 (2) , 167--179
Type: article
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