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Research project

NIHR Southampton Biomedical Research Centre 2017-2022

Staff

Lead researcher

Professor Robert Read

Chair of Infectious Diseases
Other researchers

Professor Chris Byrne

Professor of Endocrinol & Met

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology

Research interests

  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hip fracture in late adulthood
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone mineral accrual in childhood

Professor Philip Calder

Head of School

Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 
  • Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.

Professor Keith Godfrey

Associate Dean Enterprise

Professor Hasan Arshad

Prof in Allergy & Clinical Immunology

Dr Stephen Wootton PhD FAfN OBE

Associate Professor

Professor Graham Roberts

Prof in Paed. Allergy & Resp. Medicine

Professor Saul Faust MBBS, FRCPCH, PhD, FHEA, OBE

Professor Paediatric Immunology & Infect

Research outputs

Evolution of eczema, wheeze and rhinitis from infancy to early adulthood
Sadia Haider,
Sara Fontanella,
Anhar Ullah,
Stephen Turner,
Angela Simpson,
Graham Roberts,
Clare S. Murray,
John W. Holloway,
John A. Curtin,
Paul Cullinan,
Syed Hasan Arshad,
Guillem Hurault,
Raquel Granell,
& Adnan Custovic
, 2022 , American Journal of Respiratory and Critical Care Medicine , 206 (8) , 950--960
DOI: 10.1164/rccm.202110-2418OC
Type: article
Delivering brief physical activity interventions in primary care:
Louise H. Hall,
Rachael Thorneloe,
Rocio Rodriguez-Lopez,
Adam Grice,
Mangesh A. Thorat,
Katherine Bradbury,
Meghana Wadnerkar Kamble,
Grace N. Okoli,
Daniel Powell,
& Rebecca J. Beeken
, 2022 , British Journal of General Practice , 72 (716) , E209--E216
DOI: 10.3399/BJGP.2021.0312
Type: review
The FEED1 trial: protocol for a randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30–33 weeks gestational age)
Eleanor J. Mitchell,
Garry Meakin,
Josie Anderson,
Jon Dorling,
Chris Gale,
Rachel Haines,
Charlotte Kenyan,
Mark J. Johnson,
William McGuire,
Hema Mistry,
Alan Montgomery,
Sam Oddie,
Reuben Ogollah,
Phoebe Pallotti,
Christopher Partlett,
Kate F. Walker,
& Shalini Ojha
, 2022 , Trials , 23 (1)
DOI: 10.1186/s13063-021-05994-z
Type: article
Associations of maternal periconceptional alcohol consumption with offspring prehypertension/hypertension at age 6 years
Suresh Anand Sadananthan,
Navin Michael,
Mya Thway Tint,
Kashthuri Thirumurugan,
Wen Lun Yuan,
Yi Ying Ong,
Evelyn C. Law,
Jonathan T.L. Choo,
Lieng Hsi Ling,
Lynette P. Shek,
Fabian Yap,
Kok Hian Tan,
Mark Vickers,
Keith Godfrey,
Peter D. Gluckman,
Yap-Seng Chong,
Marielle Fortier,
Yung Seng Lee,
Johan G. Eriksson,
Shiao-Yng Chan,
Karen Moritz,
Sendhil Velan,
& Mary E. Wlodek
, 2022 , Journal of Hypertension , 40 (6) , 1212--1222
DOI: 10.1097/HJH.0000000000003134
Type: article
Update of the fracture risk prediction tool FRAX: A systematic review of potential cohorts and analysis plan
Lisbeth Vandenput,
H. Johansson,
E. V. McCloskey,
E. Liu,
Kristina E. Akesson,
F.A. Anderson,
R. Azagra,
C.L. Bager,
Charlotte Beaudart,
H.A. Bischoff-Ferrari,
E. Biver,
Olivier Bruyère,
J.A. Cauley,
J.R. Center,
R. Chapulat,
C. Christiansen,
Cyrus Cooper,
Carolyn J. Crandall,
Steven Cummings,
J.A.P. da Silva,
Bess Dawson-Hughes,
A. Diez-Pérez,
Alyssa B. Dufour,
J.A. Eisman,
Petra J.M. Elders,
S. Ferrari,
Y. Fujita,
S. Fujiwara,
C.C. Glüer,
I. Goldstein,
D. Goltzman,
V. Gudnason,
J. Hall,
D. Hans,
M. Hoff,
Rosemary J. Hollick,
Martijn Huisman,
M. Iki,
S. Ish-Shalom,
G. Jones,
M.K. Karlsson,
Sundeep Khosla,
D.P. Kiel,
W-P Koh,
F. Koromani,
M.A. Kotowicz,
H. Kroger,
T. Kwok,
Olivier Lamy,
Arnulf Langhammer,
Bagher Larijani,
Kurt Lippuner,
D Mellström,
Thomas Merlijn,
A. Nordstrom,
P. Nordstrom,
T.W. O'Neill,
B. Obermayer-Piestch,
Nicholas Harvey,
J A. Kanis,
C. Ohlsson,
E.S. Orwoll,
J.A. Pasco,
F. Rivadeneira,
B. Schei,
A.M. Schott,
E.J. Shiroma,
K. Siggeirsdottir,
E.M. Simonsick,
E. Sornay-Rendu,
R. Sund,
K.M.A. Swart,
P. Szulc,
J. Tamaki,
D.J. Torgerson,
N.M. Van Schoor,
T.P. van Staa,
J.C. Vilas,
N.J Wareham,
N.C. Wright,
N. Yoshimura,
M.C. Zillikens,
M. Zwart,
M. Lorentzon,
& W.D. Leslie
, 2022 , Osteoporosis International , 33 (10) , 2103--2136
DOI: 10.1007/s00198-022-06435-6
Type: review
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