About the project
Photoswitchable rotaxanes offer a new platform for highly specific receptors that can bind and release analytes in response to light. This project will focus on the synthesis of rotaxanes featuring light-responsive binding motifs, exploring their potential as a new technology for detecting and remediating chemical warfare agents.
This project will explore the design of photoactive mechanically interlocked architectures that can bind and release chemical warfare agent simulants, based on recent photoswitch-rotaxane work conducted in the Williams group. The project will involve the synthesis of complex molecules, analysis of their photophysical properties, and then their supramolecular binding affinities with mulitple analytes. This will be complemented by crystallographic studies, offering opportunities to access the world class facilities hosted at the University of Southampton.
You will be expected to actively contribute to conferences and group meetings, and will receive training in the following scientific skills (amongst others):
- complex organic synthesis and associated analysis
- photophysical characterisation
- supramolecular binding studies
- X-ray and electron diffraction techniques
We welcome applicants with an interest in applying chemistry to real-world problems in defence and security. A first degree in Chemistry is required. Familiarity with, or experience in, organic synthesis would be preferred, but applicants are not expected to have experience in all of the specialist techniques used within the project.
The project may particularly suit applicants who are interested in developing new skills and working with partners and collaborators across the University. The Williams group hosts researchers from a range of backgrounds working on varied projects, and prides itself on offering a supportive and welcoming environment.
For more information, please visit the Williams group website.
