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Research project

Characterising cancer-associated fibroblast heterogeneity in lung cancer: relating molecular phenotype to function

Staff

Lead researchers

Professor Gareth Thomas

Professor of Experimental Pathology
Research interests
  • Fibroblast biology and immunology
  • Tumour microenvironment
  • Cancer Immunotherapy
Connect with Gareth

Email: G.Thomas@soton.ac.uk

Other researchers

Dr Chris Hanley BSc, MRes, PhD

Associate Professor
Research interests
  • Tumour microenvironment
  • Fibroblasts and the Extracellular Matrix
  • Quantitative Cell Biology
Connect with Chris

Email: C.J.Hanley@soton.ac.uk

Research outputs

Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer
Christopher J. Hanley, Sara Waise, Matthew J. Ellis, Maria A. Lopez, Wai Y. Pun, Julian Taylor, Rachel Parker, Lucy M. Kimbley, Serena J. Chee, Emily C. Shaw, Jonathan West, Aiman Alzetani, Edwin Woo, Christian H. Ottensmeier, Matthew J.J. Rose-Zerilli & Gareth J. Thomas, 2023, Nature Communications, 14
DOI: 10.1038/s41467-023-35832-6
Type: article
An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing
Sara Waise, Rachel Parker, Matthew Rose-Zerilli, David Layfield, Oliver Wood, Jonathon West, Christian Ottensmeier, Gareth Thomas & Christopher Hanley, 2019, Scientific Reports, 9
DOI: 10.1038/s41598-019-45842-4
Type: article