My research is focussed in the understanding of both the evolutionary processes driving cancer progression and the multicellular ecosystem of tumour microenvironments. My group is exploiting the power of single-cell analyses to understand more about the evolution of cancer by investigating the interaction between different mutations in individual cancer cells. The accumulation of mutation generates phenotypic variability and natural selection leads to adaptions in cancer cell phenotypes, cooperation with other cancer cells and host cells in the cancer ecosystem to ensure the survival and growth of cancer.
The goal of my research is to identify the key cancer cell populations driving disease progression with the ultimate aim of providing improved clinical prognoses and directing appropriate therapeutic modalities.
- Cancer geneticsClonal evolutionTumour ecosystems
- John Goldman fellowship for future science (2016)