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Doctor Matthew Rose-Zerilli

Dr Matthew Rose-Zerilli

 BSc (Hons), PhD
Lecturer in Integrative Cancer Biology

Research interests

  • Cancer geneticsClonal evolutionTumour ecosystems

More research

Accepting applications from PhD students.


Address: Southampton General Hospital, Tremona Road Shirley, SO16 6YD (View in Google Maps)


My research is focussed in the understanding of both the evolutionary processes driving cancer progression and the multicellular ecosystem of tumour microenvironments. My group is exploiting the power of single-cell analyses to understand more about the evolution of cancer by investigating the interaction between different mutations in individual cancer cells. The accumulation of mutation generates phenotypic variability and natural selection leads to adaptions in cancer cell phenotypes, cooperation with other cancer cells and host cells in the cancer ecosystem to ensure the survival and growth of cancer.

The goal of my research is to identify the key cancer cell populations driving disease progression with the ultimate aim of providing improved clinical prognoses and directing appropriate therapeutic modalities.

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