Research project

Computational modelling to evaluate, understand and predict the placental transfer of xenobiotics as an integrated system

Staff

Associate Professor

Connect with Bram

Email: B.G.Sengers@soton.ac.uk

Professor of Bioengineering

Research interests

Connect with Xunli

Email: XL.Zhang@soton.ac.uk

Prof of Placental&Integrative Physiology

Connect with Rohan

Email: Rohan.Lewis@soton.ac.uk

Associate Professor

Research interests

Areas of Scientific Expertise:
Reproductive Cell Biology – Fundamental mechanisms of cell biology in placenta and endometrium and the impact on the intra-uterine environment, fetal development and lifelong health.Regulation of Reproductive Cell Biology – Maternal exposures and molecular regulation of cellular gene expression, phenotype and function in placenta and endometrium and the clinical translation.Disease/phenotype – Fetal growth, Obesity, Cardiometabolic programming, Subfertility, Recurrent pregnancy loss.Cellular mechanisms – Membrane transport, endocytosis, vesicular transport & signalling, gene transcription, microRNA biology, epigenetic regulation.Vitamin D - Transport, regulation, metabolism and signalling.

Connect with Jane

Email: J.K.CLEAL@soton.ac.uk

Jane K. Cleal, Emma M. Lofthouse, Bram G. Sengers & Rohan M. Lewis, 2018, The Journal of Physiology, 596(23), 5511-5522

DOI: 10.1113/JP274883

Type: review

Emma M Lofthouse, Jane K Cleal, Ita M O'Kelly, Bram G Sengers & Rohan M Lewis, 2018, Biochemical and Biophysical Research Communications

Type: article