- Areas of Scientific Expertise:
- Reproductive Cell Biology – Fundamental mechanisms of cell biology in placenta and endometrium and the impact on the intra-uterine environment, fetal development and lifelong health.Regulation of Reproductive Cell Biology – Maternal exposures and molecular regulation of cellular gene expression, phenotype and function in placenta and endometrium and the clinical translation.Disease/phenotype – Fetal growth, Obesity, Cardiometabolic programming, Subfertility, Recurrent pregnancy loss.Cellular mechanisms – Membrane transport, endocytosis, vesicular transport & signalling, gene transcription, microRNA biology, epigenetic regulation.Vitamin D - Transport, regulation, metabolism and signalling.
Can endometrial gland structure and function help us understand why some women are more at risk of infertility and miscarriage than others?
Sponsor: Rosetrees Trust
Sponsor: Royal Society
Dr Jane Cleal: Functional gene mapping of the endometrial phenotype involved in successful pregnancy: combining 3D imaging and single cell transcriptomics
Sponsor: Wellbeing of Women
Computational modelling to evaluate, understand and predict the placental transfer of xenobiotics as an integrated system
Sponsor: Biotechnology & Biological Sciences Research Council