Research project

Dr P. Elkington: Investigating multi-drug resistant tuberculosis in the 3-dimensional bioelectrospray cell culture model

Lead researchers:

Professor Paul Elkington
Research funder:

Medical Research Council
Status:

Not active

Project overview

We will develop luminescent strains of multi-drug resistant tuberculosis and investigate the response to antibiotics in our biomimetic model system.

Staff

Lead researchers

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

tuberculosis
immunopathology
diagnosis

Connect with Paul

Email: P.Elkington@soton.ac.uk

Research outputs

Advanced cellular systems to study tuberculosis treatment

Magdalena K. Bielecka & Paul Elkington, 2018, Current Opinion in Pharmacology, 42, 16-21

DOI: 10.1016/j.coph.2018.06.005

Type: article

CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains

Andrew Chancellor, Anna Tocheva, Christopher Cave-Ayland, Liku Bekele Tezera, Andrew White, Juma'a Al Dulayymi, John Bridgeman, Ivo Tews, Susan Wilson, Nikolai Lissin, Marc Tebruegge, Benjamin Marshall, Sally Sharpe, Timothy Elliott, Chris-Kriton Skylaris, Jonathan W. Essex, Mark Baird, Stephan D. Gadola, Paul Elkington & Salah Mansour, 2017, Proceedings of the National Academy of Sciences, 114(51), E10956-E10964

DOI: 10.1073/pnas.1708252114

Type: article

Bioelectrospray methodology for dissection of the host-pathogen interaction in human tuberculosis

Liku B. Tezera, Magdalena K. Bielecka & Paul T. Elkington, 2017, Bio-protocol, 7(14), 1-14

DOI: 10.21769/BioProtoc.2418

Type: article

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology

Patience T. Brace, Liku B. Tezera, Magdalena K. Bielecka, Toby Mellows, Diana Garay, Shuye Tian, Lucinda Rand, Justin Green, Sanjay Jogai, Andrew J. Steele, Timothy M. Millar, Tilman Sanchez-Elsner, Jon S. Friedland, Christopher G. Proud & Paul T. Elkington, 2017, PLOS Pathogens, 13(6)

DOI: 10.1371/journal.ppat.1006367

Type: article

A bioengineered three-dimensional cell culture platform integrated with microfluidics to address antimicrobial resistance in tuberculosis

M.K. Bielecka, L.B. Tezera, R. Zmijan, F. Drobniewski, Xunli Zhang, S. Jayasinghe & P. Elkington, 2017, mBio, 8(1)

DOI: 10.1128/mBio.02073-16

Type: article

Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model

Liku B. Tezera, Magdalena Bielecka, Andrew Chancellor, Michaela Reichmann, Basim Al Shammari, Patience Brace, Alex Batty, Annie Tocheva, Sanjay Jogai, Ben G. Marshall, Marc Tebruegge, Suwan N. Jayasinghe, Salah Mansour & Paul Elkington, 2017, eLife, 6

DOI: 10.7554/eLife.21283

Type: article

Tuberculosis: an infection-initiated autoimmune disease?

Paul Elkington, Marc Tebruegge & Salah Mansour, 2016, Trends in Immunology, 37(12), 815-818

DOI: 10.1016/j.it.2016.09.007

Type: article