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Research project

Dr P. Elkington: Investigating multi-drug resistant tuberculosis in the 3-dimensional bioelectrospray cell culture model

Project overview

We will develop luminescent strains of multi-drug resistant tuberculosis and investigate the response to antibiotics in our biomimetic model system.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

  • tuberculosis
  • immunopathology
  • diagnosis

Research outputs

Reconsidering the optimal immune response to Mycobacterium tuberculosis
Liku Bekele Tezera,
Salah Mansour,
& Paul Elkington
, 2019 , American Journal of Respiratory and Critical Care Medicine , 201 (4)
DOI: 10.1164/rccm.201908-1506PP
Type: review
Advanced cellular systems to study tuberculosis treatment
Magdalena K. Bielecka,
& Paul Elkington
, 2018 , Current Opinion in Pharmacology , 42 , 16--21
DOI: 10.1016/j.coph.2018.06.005
Type: article
Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology
Patience T. Brace,
Liku B. Tezera,
Magdalena K. Bielecka,
Toby Mellows,
Diana Garay,
Shuye Tian,
Lucinda Rand,
Justin Green,
Sanjay Jogai,
Andrew J. Steele,
Timothy M. Millar,
Tilman Sanchez-Elsner,
Jon S. Friedland,
Christopher G. Proud,
& Paul T. Elkington
, 2017 , PLOS Pathogens , 13 (6)
DOI: 10.1371/journal.ppat.1006367
Type: article
Bioelectrospray methodology for dissection of the host-pathogen interaction in human tuberculosis
Liku B. Tezera,
Magdalena K. Bielecka,
& Paul T. Elkington
, 2017 , Bio-protocol , 7 (14) , 1--14
DOI: 10.21769/BioProtoc.2418
Type: article
A bioengineered three-dimensional cell culture platform integrated with microfluidics to address antimicrobial resistance in tuberculosis
M.K. Bielecka,
L.B. Tezera,
R. Zmijan,
F. Drobniewski,
Xunli Zhang,
S. Jayasinghe,
& P. Elkington
, 2017 , mBio , 8 (1)
DOI: 10.1128/mBio.02073-16
Type: article