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Research project

Establishment of a National Network on Musculoskeletal Ageing

Project overview

Our overall aim is to establish a new national network which will underpin a step change in musculoskeletal ageing research capacity and strategy, by identifying: key tractable research priorities; developing an integrated multi-disciplinary grouping to address the identified research gaps; providing a platform to disseminate best practice; supporting Early Career Researchers (ECRs) to build research capacity and ensure longevity to current UKRI investments; and coordinating an ongoing programme of innovative studies to identify, develop and translate findings from our discovery science to clinical impact. Crucially the network will contribute to delivering the government Grand Challenge target of 5 more years of independent living by 2035, by identifying approaches to maintain mobility in old age. The network will bring together the scientific excellence of the three principal applicants. Focusing on the leading chronic non-communicable disorders of bone, muscle and joint (osteoporosis, sarcopenia, rheumatoid arthritis and osteoarthritis), the integration of these groups will galvanize a truly bench to bedside approach to provide a strong evidence base for health policy, underpinning a step change in UK musculoskeletal ageing research capability/capacity, and promoting increased healthspan.

Staff

Lead researchers

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology
Research interests
  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hi…
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone miner…
Connect with Cyrus

Email: cc@mrc.soton.ac.uk

Other researchers

Professor Nicholas Harvey

Director/Professor
Research interests
  • Lifecourse epidemiology of osteoporosis and fragility fractures
  • Understanding mechanism and development of novel interventions across lifecourse to prevent f…
Connect with Nicholas

Email: nch@mrc.soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Improving the reporting of economic evaluation in osteoporosis: the value of CHEERS 2022 statement
Mickaël Hiligsmann, Nannan Li, Cyrus Cooper, Jean-Yves Reginster, S. Silverman, C. Carswell & Don Husereau, 2022, Osteoporosis International, 33(8), 1641-1642
DOI: 10.1007/s00198-022-06400-3
Type: letterEditorial
Trabecular bone score adjustment for the Fracture Risk Assessment Tool (FRAX®)
Eugene McCloskey, Nicholas Harvey, Mattias Lorentzon, Helena Johansson, Didier Hans & John A. Kanis, 2022, Calcified Tissue International, 111(2), 226-227
DOI: 10.1007/s00223-022-00994-w
Type: letterEditorial
Assessment of activity profiles in older adults and lower limb bone parameters: Observations from the Hertfordshire Cohort Study
Camille Parsons, Elaine Dennison, Nicholas Fuggle, Micheal O. Breasail, Kevin C. Deere, Kimberly Hannam, J.H. Tobias, Cyrus Cooper & Kate Ward, 2022, Calcified Tissue International, 111(1), 13-20
DOI: 10.1007/s00223-022-00953-5
Type: article
Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database
S. Khalid, S. Calderon-Larranaga, A. Sami, S. Hawley, A. Judge, N. Arden, T.P. Van Staa, C. Cooper, B. Abrahamsen, M. Kassim Javaid & D. Prieto-Alhambra, 2022, Osteoporosis International, 33, 1579-1589
DOI: 10.1007/s00198-021-06262-1
Type: article
FREM predicts 10-year incident fracture risk independent of FRAX (R) probability: a registry-based cohort study
William D. Leslie, Soren Moller, Michael K Skjodt, Lin Yan, Bo Abrahamsen, Lisa M. Lix, Eugene V. McCloskey, Helena Johansson, Nicholas Harvey, John A. Kanis & Katrine Hass Rubin, 2022, Osteoporosis International, 33(7), 1457-1463
DOI: 10.1007/s00198-022-06349-3
Type: article
Is the skull responsive to bone mineralisation stimuli in children?
Rebecca Moon, Stefania D'angelo, Sarah Crozier, Keith Godfrey, Justin Davies, Cyrus Cooper & Nicholas Harvey, 2022, Bone, 160
DOI: 10.1016/j.bone.2022.116415
Type: article
Is it time to consider population screening for fracture risk in postmenopausal women? A position paper from the International Osteoporosis Foundation Epidemiology/Quality of Life Working Group.
Pojchong Chotiyarnwong, E. V. McCloskey, Nicholas Harvey, M. Lorentzon, Daniel Prieto-Alhambra, B. Abrahamsen, J.D Adachi, F. Borgström, Olivier Bruyère, J J Carey, P. Clark, Cyrus Cooper, Elizabeth Curtis, Elaine Dennison, Manuel Diaz Curiel, H.P. Dimai, D. Grigorie, Mickaël Hiligsmann, Patricia Khashayar, E. Michael Lewiecki, P. Lips, R.S. Lorenc, S. Ortolani, A. Papaioannou, S. Silverman, Manuel Sosa-Henríquez, Pawel Szulc, Kate Ward, N. Yoshimura & J A. Kanis, 2022, Archives of Osteoporosis, 17(1)
DOI: 10.1007/s11657-022-01117-6
Type: article