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Research project

Establishment of a National Network on Musculoskeletal Ageing

Project overview

Our overall aim is to establish a new national network which will underpin a step change in musculoskeletal ageing research capacity and strategy, by identifying: key tractable research priorities; developing an integrated multi-disciplinary grouping to address the identified research gaps; providing a platform to disseminate best practice; supporting Early Career Researchers (ECRs) to build research capacity and ensure longevity to current UKRI investments; and coordinating an ongoing programme of innovative studies to identify, develop and translate findings from our discovery science to clinical impact. Crucially the network will contribute to delivering the government Grand Challenge target of 5 more years of independent living by 2035, by identifying approaches to maintain mobility in old age. The network will bring together the scientific excellence of the three principal applicants. Focusing on the leading chronic non-communicable disorders of bone, muscle and joint (osteoporosis, sarcopenia, rheumatoid arthritis and osteoarthritis), the integration of these groups will galvanize a truly bench to bedside approach to provide a strong evidence base for health policy, underpinning a step change in UK musculoskeletal ageing research capability/capacity, and promoting increased healthspan.

Staff

Lead researchers

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology
Research interests
  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hi…
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone miner…
Connect with Cyrus

Email: cc@mrc.soton.ac.uk

Other researchers

Professor Nicholas Harvey

Director/Professor
Research interests
  • Lifecourse epidemiology of osteoporosis and fragility fractures
  • Understanding mechanism and development of novel interventions across lifecourse to prevent f…
Connect with Nicholas

Email: nch@mrc.soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Time for revival of bone biopsy with histomorphometric analysis in chronic kidney disease (CKD): moving from skepticism to pragmatism.
Maria Fusaro, Giulia Vanessa Re Sarto, Maurizio Gallieni, Laura Cosmai, Pieregiorgio Messa, Maurizio Rossini, Iacopo Chiodini, Mario Plebani, Pieter Evenepoel, Nicholas Harvey, S. Ferrari, Jorge B Cannata-Andía, Andrea  Trombetti, Maria Luisa Brandi, Markus Ketteler, Thomas L. Nickolas, John Cunningham, Syazrah Salam, Carlo Della Rocca, Aldo Scarpa, Salvatore Minisola, Fabio Malberti, Filomena Cetani, Mario Cozzolino, Sandro Mazzaferro, Luigi Morrone, Giovanni Tripepi, Martina Zaninotto, Maria Cristina Mereu, Maura Ravera, Giuseppe Cianciolo, Gaetano La Manna, Andrea Aghi, Sandro Giannini & Luca Dalle Carbonare, 2022, Nutrients, 14(9)
DOI: 10.3390/nu14091742
Type: review
The effect of fracture recency on observed 10-year fracture probability: a registry-based cohort study
William D. Leslie, Suzanne N Morin, Lisa M. Lix, Eugene V. McCloskey, Helena Johansson, Nicholas Harvey & John A. Kanis, 2022, Journal of Bone and Mineral Research, 37(5), 848-855
DOI: 10.1002/jbmr.4526
Type: article
Interdisciplinary management of FGF23-related phosphate wasting syndromes: a consensus statement on the evaluation, diagnosis and care of patients with X-linked hypophosphataemia
Andrea  Trombetti, Nasser M. Al-Daghri, Maria Luisa Brandi, Nicholas Harvey & Cyrus Cooper, 2022, Nature Reviews Endocrinology, 18(6), 366-384
DOI: 10.1038/s41574-022-00662-x
Type: article
Medical history, medication use and physical activity in adults in their eighth and ninth decade of life in the Hertfordshire Cohort Study
Gregorio Bevilacqua, Jean Zhang, Camille Parsons, Faidra Laskou, Nicholas Fuggle, Cyrus Cooper & Elaine Dennison, 2022, Experimental & Clinical Sciences Journal, 21, 695-703
DOI: 10.17179/excli2022-4874
Type: article
Incidence of hip fracture in Saudi Arabia and the development of a FRAX model
Yousef Al-Saleh, Riad Sulimani, Shaker Alomary, Yassmeen Alnajjar, Liesbeth Vandenput, Enwu Liu, Mattias Lorentzon, Nicholas Harvey, McCloskey Eugene, Helena Johansson & John A. Kanis, 2022, Archives of Osteoporosis, 17(1), 56
DOI: 10.1007/s11657-022-01085-x
Type: article
Management of patients at very high risk of osteoporotic fractures through sequential treatments
Elizabeth M. Curtis, Jean-Yves Reginster, Nasser M. Al-Daghri, Emmanuel Biver, Maria-Luisa Brandi, Etienne Cavalier, Peyman Hadji, Philippe Halbout, Nicholas C. Harvey, Mickaël Hiligsmann, M. Kassim Javaid, J.A, Kanis, Jean-Marc Kaufman, Olivier Lamy, Radmila Matijevic, Adolfo Diez-Perez, Regis Pierre Rademecker, Mario Miguel  Rosa, Thierry Thomas, Friederike Thomasius, Mila Vlaskovska, Rene Rizzoli & Cyrus Cooper, 2022, Aging Clinical and Experimental Research, 34(4), 695-714
DOI: 10.1007/s40520-022-02100-4
Type: review
Epidemiology of hip fracture in Qatar and development of a country specific FRAX model
N. Abdulla, O S Alsaed, A. Luft, F. Alam, I. Abdulmomen, S. Al Emadi, Nicholas Harvey, E. Liu, Lisbeth Vandenput, M. Lorentzon, E.V. McCloskey, J A. Kanis & H. Johansson, 2022, Archives of Osteoporosis, 17(1)
DOI: 10.1007/s11657-022-01083-z
Type: article