Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Kathryn V. Dalrymple, Sarah El-Heis & Keith Godfrey,
2022, Current Opinion in Clinical Nutrition and Metabolic Care, 25(3), 203-208
Type: review
Ilana S. Berman, Katie A. McLaughlin, Nim Tottenham, Keith Godfrey, Teresa Seeman, Eric Loucks, Stephen Suomi, Andrea Danese & Margaret A. Sheridan,
2022, Development and Psychopathology, 34(2), 499-511
Type: article
Englebert A. Nonterah, Paul Welaga, Samuel T. Chatio, Sarah Kehoe, Winfred Ofosu, Kate Ward, Keith Godfrey, Abraham R. Oduro & Marie-Louise Newell,
2022, Maternal & Child Nutrition, 18(2)
DOI: 10.1111/mcn.13313
Type: article
Debbie S. Thompson, Patrice M. Francis-Emmanuel, Alan T. Barnett, Clive Osmond, Mark Hanson, Christopher Byrne, Peter D. Gluckman, Terrence E. Forrester & Michael S. Boyne,
2022, Journal of Developmental Origins of Health and Disease, 13(6), 750-756
Type: article
Mukkesh Kumar, Li Chen, Karen Mei Ling Tan, Li Ting Ang, Cindy Ho, Gerard Wong, S.E. Soh, Kok Hian Tan, Jerry K.Y. Chan, Keith Godfrey, Shiao-Yng Chan, Mary Foong-Fong Chong, John E. Connolly, Yap-Seng Chong, Johan G. Eriksson, Mengling Feng & Neerja Karmani,
2022, Diabetes Research and Clinical Practice, 185
Type: article
Tosha Ashish Kahlan, Evelyn X.L. Loo, Lynette Pei-Chi Shek , Michael S. Kramer, Carolina Un Lam, Bindu Karunakaran, Hugo van Bever, Anne Eng Neo Goh, Yap-Seng Chong, Bee Wah Lee, Kok Hian Tan, Seang-Mei Saw, Keith Godfrey & C.-Y.S. Hsu,
2022, Pediatric Allergy and Immunology, 33(1)
DOI: 10.1111/pai.13675
Type: letterEditorial
Kathryn V. Dalrymple, Christina Vogel, Keith Godfrey, Janis Baird, Nicholas Harvey, Mark Hanson, Cyrus Cooper, Hazel Inskip & Sarah Crozier,
2021, International Journal of Obesity
Type: article