Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
S.L. Loy, Daniel Wei Keong Chan, Chee Wai Ku, Yin Bun Cheung, Keith Godfrey, Karen Mei Ling Tan, Yap-Seng Chong, Lynette P. Shek, Kok Hian Tan, Shiao-Yng Chan, Jerry Kok Yen Chan & Fabian Yap,
2021, American Journal of Obstetrics and Gynecology
Type: article
Karen Mei Ling Tan, Mya Thway Tint, Navin Michael, Fabian Yap, Yap-Seng Chong, Kok Hian Tan, Keith Godfrey, Anis Larbi, Yung Seng Lee, Shiao-Yng Chan, Marielle V. Fortier, Johan G. Eriksson & Neerja Karnani,
2021, International Journal of Obesity
Type: article
Elie Antoun, Emma Garratt, Andrea Taddei, Mark Burton, Sheila Barton, Philip Titcombe, Leo Westbury, Alicia Baczynska, Eugenia Migliavacca, Jerome N. Feige, Holly Emma Syddall, Elaine Dennison, Richard Dodds, Helen Roberts, Peter Richardson, Avan A. Sayer, Sarah Shaw, Cyrus Cooper, Joanna D. Holbrook, Harnish Patel, Keith Godfrey & Karen Lillycrop,
2021, Journal of Cachexia, Sarcopenia and Muscle, 13(1), 240 - 253
DOI: 10.1002/jcsm.12876
Type: article
Jonathan Y. Huang, Shirong Cai, Zhongwei Huang, Tint Mya, Wen Lun Yuan, Izzuddin M. Aris, Keith Godfrey, Neerja Karmani, Yung Seng Lee, Jerry Kok Yen Chan, Yap-Seng Chong, Johan G. Eriksson & Shiao-Yng Chan,
2021, Nature Communications, 12(1)
Type: article
Ling-Wei Chen, Shu-E. Soh, Mya Thway Tint, See Ling Loy, Fabian Yap, Kok Hian Tan, Yung Seng Lee, Lynette Pei-Chi Shek , Keith Godfrey, Peter D. Gluckman, Johan G. Eriksson, Yap-Seng Chong & Shiao-Yng Chan,
2021, Scientific Reports, 11(1)
Type: article
Kathryn V. Dalrymple, Angela Flynn, Paul T. Seed, Annette Briley, Majella O’Keeffe, Keith Godfrey & Lucilla Poston,
2021, Pediatric Obesity, 16(11)
DOI: 10.1111/ijpo.12801
Type: article
Michael Penkler, Chandni M Jacob, Ruth Müller, Martha Kenney, Shane A Norris, Clarissa P da Costa, Sarah S Richardson, Tessa J Roseboom & Mark Hanson,
2021, Journal of Developmental Origins of Health and Disease, 1-4
Type: article