Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Nida Ziauddeen, Jonathan Huang, Elizabeth Taylor, Paul Roderick, Keith Godfrey & Nisreen Alwan,
2021, International Journal of Obesity
Type: article
Ives Yubin Lim, Xinyi Lin, Ai Ling Teh, Yonghui Wu, Li Chen, Menglan He, Shiao-Yng Chan, Julia L. MacIsaac, Jerry KY Chan, Kok Hian Tan, Mary Foong-Fong Chong, Michael S. Kobor, Keith Godfrey, Michael J. Meaney, Yung Seng Lee, Johan G. Eriksson, Peter D. Gluckman, Yap-Seng Chong & Neerja Karnani,
2021, Journal of Clinical Endocrinology & Metabolism
Type: article
Shan-Xuan Lim, See Ling Loy, Marjorelee T. Colega, Jun Shi Lai, Keith Godfrey, Yung Seng Lee, Kok Hian Tan, Fabian Yap, Lynette Pei-Chi Shek , Yap-Seng Chong, Johan G. Eriksson, Jerry Kok Yen Chan, Shiao-Yng Chan & Mary Foong-Fong Chong,
2021, American Journal of Clinical Nutrition
DOI: 10.1093/ajcn/nqab344
Type: article
Hui Xing Lau, Sarah El-Heis, Qai Ven Yap, Yiong Huak Chan, Cheryl Pei-Ting Tan, Neerja Karmani, Karen Mei Ling Tan, Elizabeth Huiwen Tham, Anne Eng Neo Goh, Oon Hoe Teoh, Kok Hian Tan, Johan Gunnar Eriksson, Yap-Seng Chong, Mary F.F. Chong, Hugo van Bever, Bee Wah Lee, Lynette P. Shek, Keith Godfrey & Evelyn X.L. Loo,
2021, Clinical & Experimental Allergy, 51(10), 1346-1360
DOI: 10.1111/cea.13953
Type: article
Neha Sharma, Oliver C. Watkins, Anne H.Y. Chu, Wayne Cutfield, Keith Godfrey, Hannah E.J. Yong & Shiao-Yng Chan,
2021, Nutrition Research Reviews
Type: article
Wei Wei Pang, Donna T. Geddes, Ching-Tat Lai, Shiao-Yng Chan, Yiong Huak Chan, Clara Y. Cheong, Doris Fok, Mei Chien Chua, Sok Bee Lim, Jonathan Y. Huang, Shikha Pundir, Kok Hian Tan, Fabian Yap, Keith Godfrey, Peter D. Gluckman, Lynette P. Shek, Mark H. Vickers, Johan G. Eriksson, Yap-Seng Chong & Mary E. Wlodek,
2021, American Journal of Clinical Nutrition, 114(3), 1219-1228
DOI: 10.1093/ajcn/nqab142
Type: article
Noor H. A. Suaini, Gaik Chin Yap, Bui Do Phuong Tung, Evelyn X.L. Loo, Anne Eng Neo Goh, Oon Hoe Teoh, Kok Hian Tan, Keith Godfrey, Bee Wah Lee, Lynette Pei-Chi Shek , Hugo van Bever, Yap-Seng Chong & Elizabeth Huiwen Tham,
2021, Clinical & Experimental Allergy, 51(9), 1195-1206
DOI: 10.1111/cea.13993
Type: article