Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Kathryn Dalrymple, Florence A S Tydeman, Paul D. Taylor, Angela Flynn, Majella O’Keeffe, Annette Briley, Paramala Santosh, Louise Hayes, Stephen C. Robson, Scott M. Nelson, Naveed Sattar, Melissa K Whitworth, Harriet L. Mills , Claire Singh, Paul T. Seed, Sara L. White, Deborah A. Lawlor, Keith Godfrey & Lucilla Poston,
2020, Pediatric Obesity, 16(3), 1-11
DOI: 10.1111/ijpo.12725
Type: article
See Ling Loy, Rachael Si Xuan Loo, Keith Godfrey, Yap-Seng Chong, Lynette Pei-Chi Shek , Kok Hian Tan, Mary Foong-Fong Chong, Jerry Kok Yen Chan & Fabian Yap,
2020, Nutrients, 12(9), 2783
DOI: 10.3390/nu12092783
Type: review
Ella Seccombe, University Hospital Southampton Department, Matthew David Wynne, Cornelius Clancy, Keith Godfrey & Adam Fityan,
2020, Photodermatology, Photoimmunology & Photomedicine
DOI: 10.1111/phpp.12604
Type: article
Yi Ying Ong, Suresh Anand Sadananthan, Izzuddin M. Aris, Mya Thway Tint, Wen Lun Yuan, Jonathan Y. Huang, Yiong Huak Chan, Sharon Ng, See Ling Loy, Sendhil Velan, Marielle V. Fortier, Keith Godfrey, Lynette Shek, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Jonathan Tze Liang Choo, Lieng Hsi Ling, Karen Tan, Li Chen, Neerja Karnani, Yap-Seng Chong, Johan G. Eriksson, Mary E. Wlodek, Shiao-Yng Chan, Yung Seng Lee & Navin Michael,
2020, International Journal of Epidemiology, 49(5)
DOI: 10.1093/ije/dyaa143
Type: article
Elise M. Philips, Susana Santos, Leonardo Trasande, Juan J. Aurrekoetxea, Andrea von Berg, Sarah Crozier, Keith Godfrey & Hazel Inskip,
2020, PLoS Medicine, 17(8), 1-25
Type: article
Mary Foong-Fong Chong, Keith Godfrey, Peter Gluckman, Kok Hian Tan, Lynette P. Shek, Michael Meaney, Jerry Kok Yen Chan, Fabian Yap, Yung Seng Lee & Yap-Seng Chong,
2020, Proceedings of the Nutrition Society, 79(3), 253-258
Type: article
Angela Flynn, John M.D. Thompson, Kathryn Dalrymple, Clare R. Wall, Shahina Begum, Jaijus P. Johny, Wayne Cutfield, Robyn North, Lesley M.E. McCowan, Keith Godfrey, Edwin A. Mitchell & Lucilla Poston,
2020, British Journal of Nutrition, 124(2), 217-224
Type: article