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Research project

Hanson RG/15/17/31749 Epigenetic Biomarkers and Determinants of Cardiovascular Risk in Children

Project overview

This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.

Staff

Lead researchers

Emeritus Professor Mark Hanson

Research interests
  • Developmental Origins of Health and Disease (DOHaD)
  • Maternal and Child Health
  • Developmental nutrition and epigenetic mechanisms
Connect with Mark

Email: M.Hanson@soton.ac.uk

Other researchers

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology
Research interests
  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hi…
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone miner…
Connect with Cyrus

Email: cc@mrc.soton.ac.uk

Professor Keith Godfrey

Associate Dean – KEE
Connect with Keith

Email: kmg@mrc.soton.ac.uk

Emeritus Professor Hazel Inskip MSc, PhD, FFPH

Connect with Hazel

Email: hmi@mrc.soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Implication of gut microbiota in the association between infant antibiotic exposure and childhood obesity and adiposity accumulation
Ling-Wei Chen, Jia Xu, S.E. Soh, I.M. Aris, Tint Mya, Peter D. Gluckman, Kok Hian Tan, Lynette P. Shek, Yap-Seng Chong, Fabian Yap, Keith Godfrey, Jack A. Gilbert, Neerja Karnani & Yung Seng Lee, 2020, International Journal of Obesity, 44(7), 1508-1520
DOI: 10.1038/s41366-020-0572-0
Type: article
Is breastfeeding associated with later child eating behaviours?
Wei Wei Pang, K. McCrickerd, Phaik Ling Quah, Anna Fogel, Izzuddin M. Aris, Wen Lun Yuan, Doris Fok, Mei Chien Chua, Sok Bee Lim, Lynette P. Shek, Shiao-Yng Chan, Kok Hian Tan, Fabian Yap, Keith Godfrey, Michael J. Meaney, Mary E. Wlodek, Johan Eriksson, Michael S. Kramer, Ciaran G Forde, Mary F.F. Chong & Yap-Seng Chong, 2020, Appetite, 150
DOI: 10.1016/j.appet.2020.104653
Type: article
Maternal glycemia during pregnancy and child carotid intima media thickness, pulse wave velocity, and augmentation index
Wen Lun Yuan, J. Lin, Michael S. Kramer, Keith Godfrey, Peter D. Gluckman, Yap-Seng Chong, Lynette P. Shek, Kok Hian Tan, Shiao-Yng Chan, Johan G. Eriksson, Fabian Yap, Yung Seng Lee, Jonathan T.L. Choo & L.H. Ling, 2020, Journal of Clinical Endocrinology & Metabolism, 105(7), 1-10
DOI: 10.1210/clinem/dgaa211
Type: article
Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study
Tint Mya, Suresh Sadananthan, Shu-E Soh, Izzuddin M. Aris, Navin Michael, Kok H. Tan, Lynette P. Shek, Fabian Yap, Peter D. Gluckman, Y-S Chong, Keith Godfrey, Sendhil Velan, Shiao-Yng Chan, Johan G. Eriksson, Marielle V. Fortier, Cuilin Zhang & Yung Seng Lee, 2020, American Journal of Clinical Nutrition, 112(1), 39-47
DOI: 10.1093/ajcn/nqaa055
Type: article
Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy
Luiza Borges Manna, Georgia Papacleovoulou, Flavia Flaviani, Vanessa Formigo-Pataia, Asaad Qadri, Shadi Abu-Hayyeh, Saraid Mcilvride, Eugene Jansen, Peter Dixon, Jennifer Chambers, Marta Vazquez Lopez, Annika Wahlstroem, Negusse Kitaba, Hanns-Ulrich Marschall, Keith Godfrey, Karen Lillycrop & Catherine Williamson, 2020, Scientific Reports, 10(1)
DOI: 10.1038/s41598-020-67301-1
Type: article
Early Nutrition eAcademy Southeast Asia e-learning for enhancing knowledge on nutrition during the first 1,000 days of life
Brigitte Brands, Sirinuch Chomtho, Umaporn Suthutvoravut, Christopher Chiong Meng Boey, Swee Fong Tang, Keith Godfrey & Berthold Koletzko, 2020, Nutrients, 12(6), 1-12
DOI: 10.3390/nu12061817
Type: article
Eating behaviors moderate the associations between risk factors in the first 1,000 days and adiposity outcomes at 6 years of age
Anna Fogel, Keri McCrickerd, Izzuddin M. Aris, Ai Ting Goh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette P. Shek, Michael J. Meaney, Birit F.P. Broekman, Keith Godfrey, Mary Foong-Fong Chong, Shirong Cai, Wei Wei Pang, Wen Lun Yuan, Yung Seng Lee & Ciaran G Forde, 2020, American Journal of Clinical Nutrition, 997-1006
DOI: 10.1093/ajcn/nqaa052
Type: article