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Research project

TISuMR: Integrated Tissue Slice Culture and NMR Metabolomics – A Novel Approach Towards Systemic

  • Research funder:
    European Union
  • Status:
    Not active

Project overview

This international collaboration, led by Southampton, aims to provide a radically new technological platform for the integrated culture and NMR observation of liver tissue slices, with the immediate objective to elucidate the mechanism of liver damage by cholestasis.

Research outputs

Fully automated characterization of protein-peptide binding by microfluidic 2D NMR
Marek Plata, Manvendra Sharma, Marcel Utz & Jörn M. Werner, 2022, Journal of the American Chemical Society, 145(5), 3204–3210
DOI: 10.1021/jacs.2c13052
Type: article
Time-resolved non-invasive metabolomic monitoring of a single cancer spheroid by microfluidic NMR
2021, Scientific Reports, 11(1)
DOI: 10.1038/s41598-020-79693-1
Type: article
Synergies between hyperpolarized NMR and microfluidics: a review
2021, Progress in Nuclear Magnetic Resonance Spectroscopy
DOI: 10.1016/j.pnmrs.2021.09.001
Type: review
Microfluidic platform for serial mixing experiments with in operando nuclear magnetic resonance spectroscopy
Marek Plata, William G Hale, Manvendra Sharma, Jorn Werner & Marcel Utz, 2021, Lab on a Chip, 21(8), 1598-1603
DOI: 10.1039/D0LC01100B
Type: article
Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance
2021, Chemistry, 2021(3), 948–956
DOI: 10.31635/ccschem.021.202100773
Type: article
5-axis CNC micro-milling for rapid, cheap and background free NMR micro-coils
2020, Analytical Chemistry
DOI: 10.1021/acs.analchem.0c03126
Type: article
Modular transmission line probes for microfluidic nuclear magnetic resonance spectroscopy and imaging
2019, Journal of Magnetic Resonance, 303, 75-81
DOI: 10.1016/j.jmr.2019.04.007
Type: article