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Research project

TISuMR: Integrated Tissue Slice Culture and NMR Metabolomics – A Novel Approach Towards Systemic

  • Research groups:
  • Lead researcher:
    Professor Marcel Utz
  • Research funder:
    European Union
  • Status:
    Not active

Project overview

This international collaboration, led by Southampton, aims to provide a radically new technological platform for the integrated culture and NMR observation of liver tissue slices, with the immediate objective to elucidate the mechanism of liver damage by cholestasis.

Staff

Lead researcher

Professor Marcel Utz

Professorial Fellow-Research

Research interests

  • Integration of microfluidic lab-on-a-chip technology with NMR spectroscopy and imaging;
  • Behaviour of complex materials.

Collaborating research institutes, centres and groups

Magnetic Resonance

Our main focus is finding ways to extend the timescale over which magnetic resonance can be made.

Research outputs

5-axis CNC micro-milling for rapid, cheap and background free NMR micro-coils
Vincent Moxley-Paquette,
Daniel Lane,
Ronald Soong,
Paris Ning,
Monica Bastawrous,
Bing Wu,
Maysam Zamani Pedram,
Md Aminul Haque Talukder,
Ebrahim Ghafar-Zadeh,
Dimitri Zverev,
Richard Martin,
Bob Macpherson,
Mike Vargas,
Daniel Schmidig,
Stefan Graf,
Thomas Frei,
Danijela Al Adwan-Stojilkovic,
Peter De Castro,
Falko Busse,
Wolfgang Bermel,
Till Kuehn,
Rainer Kuemmerle,
Michael Fey,
Frank Decker,
Henry Stronks,
Ruby May A. Sullan,
Marcel Utz,
& André J. Simpson
, 2020 , Analytical Chemistry
DOI: 10.1021/acs.analchem.0c03126
Type: article
Modular transmission line probes for microfluidic nuclear magnetic resonance spectroscopy and imaging
Manvendra Sharma,
& Marcel Utz
, 2019 , Journal of Magnetic Resonance , 303 , 75--81
DOI: 10.1016/j.jmr.2019.04.007
Type: article
Integration of ex-vivo precision-cut liver slice (PCLS) culture with microfluidic NMR metabolomics
Bishnubrata Patra,
Manvendra Sharma,
Ruby Karsten,
Maciej Grajewski,
Sabeth Verpoorte,
& Marcel Utz
, 2019
Type: conference
High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets
William Hale,
Gabriel Rossetto,
Rachel Greenhalgh,
Graeme Finch,
& Marcel Utz
, 2018 , Lab on a Chip , 2018 (19) , 3018--3024
DOI: 10.1039/C8LC00712H
Type: article