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Research project

Long-lived Nuclear Hyperpolarization of Methyl Groups

Project overview

This project consists of the hyperpolarization of long-lived states in methyl groups and their isotopomers. The project makes use of solution NMR and dissolution-DNP equipment.

Staff

Lead researcher

Professor Malcolm Levitt

Professor of Chemistry

Research interests

  • Magnetic Resonance
  • Endofullerenes
Other researchers

Professor Richard Brown

Professor of Organic Chemistry

Collaborating research institutes, centres and groups

Magnetic Resonance

Our main focus is finding ways to extend the timescale over which magnetic resonance can be made.

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Versatile magnetic resonance singlet tags compatible with biological conditions
Stefan Gloggler,
Stuart Elliott,
Gabriele Stevanato,
Richard C.D. Brown,
& Malcolm H. Levitt
, 2017 , RSC Advances , 7 (55) , 34574--34578
DOI: 10.1039/C7RA05196D
Type: article
Origins of small proton chemical shift differences in monodeuterated methyl groups
O. Maduka Ogba,
Stuart Elliott,
David A. Kolin,
Lynda J. Brown,
Sebastian Cevallos,
Stuart Sawyer,
Malcolm H. Levitt,
& Daniel J. O'Leary
, 2017 , Journal of Organic Chemistry , 82 (17) , 8943–8949
DOI: 10.1021/acs.joc.7b01356
Type: article
Dynamic nuclear polarization of long-lived nuclear spin states in methyl groups
Jean-Nicolas Dumez,
Basile Vuichoud,
Daniele Mammoli,
Aurélien Bornet,
Arthur C. Pinon,
Gabriele Stevanato,
Benno Meier,
Geoffery Bodenhausen,
Sami Jannin,
& Malcolm H. Levitt
, 2017 , The Journal of Physical Chemistry Letters , 8 (15) , 3549--3555
DOI: 10.1021/acs.jpclett.7b01512
Type: article
Long-lived nuclear spin states in monodeuterated methyl groups
Stuart Elliott,
Lynda J. Brown,
Jean-Nicolas Dumez,
& Malcolm H. Levitt
, 2016 , Physical Chemistry Chemical Physics , 18 (27) , 17965--17972
DOI: 10.1039/C6CP03619H
Type: article
Long-lived nuclear spin states in rapidly rotating CH2D groups
Stuart Elliott,
Lynda J. Brown,
Jean-Nicolas Dumez,
& Malcolm H. Levitt
, 2016 , Journal of Magnetic Resonance , 272 , 87--90
DOI: 10.1016/j.jmr.2016.09.009
Type: article