Research project

Long-lived Nuclear Hyperpolarization of Methyl Groups

Research groups:

Organic Chemistry, Synthesis, Catalysis
Lead researchers:

Professor Malcolm Levitt
Other researchers:

Professor Richard Brown
Research funder:

EPSRC
Status:

Not active

Project overview

This project consists of the hyperpolarization of long-lived states in methyl groups and their isotopomers. The project makes use of solution NMR and dissolution-DNP equipment.

Staff

Lead researchers

Professor Malcolm Levitt

Professor of Chemistry

Research interests

Magnetic Resonance
Endofullerenes

Connect with Malcolm

Email: mhl@soton.ac.uk

Other researchers

Professor Richard Brown

Professor of Organic Chemistry

Research interests

Organic synthesis
Total synthesis of natural products
Asymmetric synthesis

Connect with Richard

Email: R.C.Brown@soton.ac.uk

Collaborating research institutes, centres and groups

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Dynamic nuclear polarization of long-lived nuclear spin states in methyl groups

Jean-Nicolas Dumez, Basile Vuichoud, Daniele Mammoli, Aurélien Bornet, Arthur C. Pinon, Gabriele Stevanato, Benno Meier, Geoffery Bodenhausen, Sami Jannin & Malcolm H. Levitt, 2017, The Journal of Physical Chemistry Letters, 8(15), 3549-3555

DOI: 10.1021/acs.jpclett.7b01512

Type: article

Origins of small proton chemical shift differences in monodeuterated methyl groups

O. Maduka Ogba, Stuart Elliott, David A. Kolin, Lynda J. Brown, Sebastian Cevallos, Stuart Sawyer, Malcolm H. Levitt & Daniel J. O'Leary, 2017, The Journal of Organic Chemistry, 82(17), 8943–8949

DOI: 10.1021/acs.joc.7b01356

Type: article

NMR of molecular endofullerenes dissolved in a nematic liquid crystal

Karel Kouril, Christopher Wickens, Benno Meier, Shamim Alom, John Grasvik, Richard J. Whitby & Malcolm H. Levitt, 2017, Physical Chemistry Chemical Physics, 2017(19), 11793-11801

DOI: 10.1039/C7CP00906B

Type: article

Singlet NMR methodology in two-spin-1/2 systems

Giuseppe Pileio, 2017, Progress in Nuclear Magnetic Resonance Spectroscopy, 98-99, 1-19

DOI: 10.1016/j.pnmrs.2016.11.002

Type: article

Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems

James Eills, Gabriele Stevanato, Christian Bengs, Stefan Gloggler, Stuart Elliott, Javier Alonso Valdesueiro, Giuseppe Pileio & Malcolm Levitt, 2017, Journal of Magnetic Resonance, 274, 163-172

DOI: 10.1016/j.jmr.2016.11.010

Type: article

Versatile magnetic resonance singlet tags compatible with biological conditions

Stefan Gloggler, Stuart Elliott, Gabriele Stevanato, Richard C.D. Brown & Malcolm H. Levitt, 2017, RSC Advances, 7(55), 34574-34578

DOI: 10.1039/C7RA05196D

Type: article

Long-lived nuclear spin states in rapidly rotating CH2D groups

Stuart Elliott, Lynda J. Brown, Jean-Nicolas Dumez & Malcolm H. Levitt, 2016, Journal of Magnetic Resonance, 272, 87-90

DOI: 10.1016/j.jmr.2016.09.009

Type: article