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Research project

NIHR Southampton Biomedical Research Centre 2017-2022

Staff

Lead researcher

Professor Robert Read

Chair of Infectious Diseases
Other researchers

Professor Chris Byrne

Professor of Endocrinol & Met

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology

Research interests

  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hip fracture in late adulthood
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone mineral accrual in childhood

Professor Philip Calder

Head of School

Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 
  • Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.

Professor Keith Godfrey

Associate Dean Enterprise

Professor Hasan Arshad

Prof in Allergy & Clinical Immunology

Dr Stephen Wootton PhD FAfN OBE

Associate Professor

Professor Graham Roberts

Prof in Paed. Allergy & Resp. Medicine

Professor Saul Faust MBBS, FRCPCH, PhD, FHEA, OBE

Professor Paediatric Immunology & Infect

Research outputs

Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
Maria Sparreman Mikus,
Johan Kolmert,
Lars I Andersson,
Jörgen Östling,
Richard G Knowles,
Cristina Gómez,
Magnus Ericsson,
John-Olof Thörngren,
Payam Emami Khoonsari,
Barbro Dahlén,
Maciej Kupczyk,
Bertrand De Meulder,
Charles Auffray,
Per S Bakke,
Bianca Beghe,
Elisabeth H Bel,
Massimo Caruso,
Pascal Chanez,
Bo Chawes,
Stephen J Fowler,
Mina Gaga,
Thomas Geiser,
Mark Gjomarkaj,
Ildikó Horváth,
Peter H Howarth,
Sebastian L Johnston,
Guy Joos,
Norbert Krug,
Paolo Montuschi,
Jacek Musial,
Ewa Niżankowska-Mogilnicka,
Henric K Olsson,
Alberto Papi,
Klaus F Rabe,
Thomas Sandström,
Dominick E Shaw,
Nikolaos M Siafakas,
Mathias Uhlén,
John H Riley,
Stewart Bates,
Roelinde J M Middelveld,
Craig E Wheelock,
Kian Fan Chung,
Ian M Adcock,
Peter J Sterk,
Ratko Djukanovic,
Peter Nilsson,
Sven-Erik Dahlén,
Anna James,
&
, 2022 , European Respiratory Journal , 59 (2)
DOI: 10.1183/13993003.00142-2021
Type: article
Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial
Grace Li,
Federica Cappuccini,
Natalie G Marchevsky,
Parvinder K Aley,
Robert Aley,
Rachel Anslow,
,
,
Sagida Bibi,
Katrina Cathie,
Elizabeth Clutterbuck,
Saul N Faust,
Shuo Feng,
Paul T Heath,
Simon Kerridge,
Alice Lelliott,
Yama Mujadidi,
Khuen Foong Ng,
Sarah Rhead,
Hannah Roberts,
Hannah Robinson,
Marion R Roderick,
Nisha Singh,
David Smith,
Matthew D Snape,
Rinn Song,
Karly Tang,
Andy Yao,
Xinxue Liu,
Teresa Lambe,
& Andrew J Pollard
, 2022 , The Lancet , 399 (10342) , 2212--2225
DOI: 10.1016/S0140-6736(22)00770-X
Type: article
Safety and immunogenicity of the inactivated whole-virus adjuvanted COVID-19 vaccine VLA2001
Rajeka Lazarus,
Christian Taucher,
Claire Brown,
Irena Corbic,
Leon Danon,
Katrin Dubischar,
,
,
Christopher J A Duncan,
Susanne Eder-Lingelbach,
Saul N Faust,
Christopher Green,
Karishma Gokani,
Romana Hochreiter,
Johanna Kellett Wright,
Dowan Kwon,
Alexander Middleditch,
Alasdair P S Munro,
Kush Naker,
Florentina Penciu,
David Price,
Benedicte Querton,
Tawassal Riaz,
Amy Ross-Russell,
Amada Sanchez-Gonzalez,
Hayley Wardle,
Sarah Warren,
& Adam Finn
, 2022 , Journal of Infection , 85 (3) , 306 -- 317
DOI: 10.1016/j.jinf.2022.06.009
Type: article
Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial
Alasdair P S Munro,
Shuo Feng,
Leila Janani,
Victoria Cornelius,
Parvinder K Aley,
Gavin Babbage,
,
David Baxter,
Marcin Bula,
Katrina Cathie,
Krishna Chatterjee,
Kate Dodd,
Yvanne Enever,
Ehsaan Qureshi,
Anna L Goodman,
Christopher A Green,
Linda Harndahl,
John Haughney,
Alexander Hicks,
Agatha A van der Klaauw,
Nasir Kanji,
Vincenzo Libri,
Martin J Llewelyn,
Alastair C McGregor,
Mina Maallah,
Angela M Minassian,
Patrick Moore,
Mehmood Mughal,
Yama F Mujadidi,
Kyra Holliday,
Orod Osanlou,
Rostam Osanlou,
Daniel R Owens,
Mihaela Pacurar,
Adrian Palfreeman,
Daniel Pan,
Tommy Rampling,
Karen Regan,
Stephen Saich,
Tanveer Bawa,
Dinesh Saralaya,
Sunil Sharma,
Ray Sheridan,
Emma C Thomson,
Shirley Todd,
Chris Twelves,
Robert C Read,
Sue Charlton,
Bassam Hallis,
Mary Ramsay,
& Saul N Faust
, 2022 , The Lancet Infectious Diseases , 22 (8) , 1131--1141
DOI: 10.1016/S1473-3099(22)00271-7
Type: article
Mapping atopic dermatitis and anti-IL-22 response signatures to Type 2-low severe neutrophilic asthma
,
Yusef Eamon Badi,
Ana B Pavel,
Stelios Pavlidis,
John H Riley,
Stewart Bates,
Nazanin Zounemat Kermani,
Richard Knowles,
Johan Kolmert,
Craig E Wheelock,
Sally Worsley,
Mohib Uddin,
Kjell Alving,
Per S Bakke,
Annelie Behndig,
Massimo Caruso,
Pascal Chanez,
Louise J Fleming,
Stephen J Fowler,
Urs Frey,
Peter Howarth,
Ildikó Horváth,
Norbert Krug,
Anke H Maitland-van der Zee,
Paolo Montuschi,
Graham Roberts,
Marek Sanak,
Dominick E Shaw,
Florian Singer,
Peter J Sterk,
Ratko Djukanovic,
Sven-Eric Dahlen,
Yi-Ke Guo,
Kian Fan Chung,
Emma Guttman-Yassky,
& Ian M Adcock
, 2022 , Journal of Allergy and Clinical Immunology , 149 (1) , 89--101
DOI: 10.1016/j.jaci.2021.04.010
Type: article