R Carare - Physiology of Perivascular drainage of the brain and how it is affected by advancing age

Staff

Lead researchers

Professor Roxi Carare

Head of School

Research interests

Causes and new therapeutic strategies for dementias and other neurodegenerative diseases
New early diagnostic measures in dementia based on biomarkers from the nose
Drug delivery to the brain

Connect with Roxi

Email: R.O.Carare@soton.ac.uk

Other researchers

Professor James Nicoll

Connect with James

Email: J.Nicoll@soton.ac.uk

Research outputs

The fine anatomy of the perivascular compartment in the human brain

Matthew MacGregor Sharp, Diederik Bulters, Sebastian Brandner, Janice Holton, Ajay Verma, David J. Werring & Roxana O. Carare, 2019, Neuropathology and Applied Neurobiology, 45(3), 305-308

DOI: 10.1111/nan.12480

Type: article

Loss of Clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Aleksandra Wojtas, Silvia Kang, Benjamin Olley, Maureen Gatherer, Mitsuru Shinohara, Patricia Lozano, Chia-Chen Liu, Aishe Kurti, Kelsey Baker, Dennis Dickson, Mei Yue, Leonard Petrucelli, Guojun Bu, Roxana Carare & John D. Fryer, 2017, Proceedings of National Academy of Sciences of the United States of America, 114(33), E6962-E6971

DOI: 10.1073/pnas.1701137114

Type: article

Deposition of amyloid-beta in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy

Abby Keable, Kate Fenna, Ho Ming Yuen, David A. Johnston, Neil R. Smyth, Colin Smith, Rustam Al-Shahi Salman, Neshika Samarasekera, James A.R. Nicoll, Johannes Attems, Rajesh N. Kalaria, Roy O. Weller & Roxana-Octavia Carare, 2016, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(5), 1037-1046

DOI: 10.1016/j.bbadis.2015.08.024

Type: article

Quantification of molecular interactions between ApoE, amyloid-beta (A?) and laminin: relevance to accumulation of A? in Alzheimer's disease

Jurgita Zekonyte, Kenji Sakai, James A.R. Nicoll, Roy O. Weller & Roxana O. Carare, 2016, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862(5), 1047-1053

DOI: 10.1016/j.bbadis.2015.08.025

Type: article

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

Alan W.J. Morris, Matthew MacGregor Sharp, Nazira J. Albargothy, Rute Fernandes, Cheryl A Hawkes, Ajay Verma, Roy O Weller & Roxana O. Carare, 2016, Acta Neuropathologica, 131(5), 725-736

DOI: 10.1007/s00401-016-1555-z

Type: article

Pathophysiology of lymphatic drainage of the central nervous system: implications for the pathophysiology of multiple sclerosis

Roy O. Weller, Roxanna O. Carare, Cheryl A. Hawkes & Ian Galea, 2015

DOI: 10.1016/B978-0-12-800763-1.00019-1

Type: bookChapter

Are you also what your mother eats? Distinct proteomic portrait as a result of maternal high-fat diet in the cerebral cortex of the adult mouse

A. Manousopoulou, J. Woo, C.H. Woelk, H. Johnston, A. Singhania, C. Hawkes, Spiros D. Garbis & Roxana-Octavia Carare, 2015, International Journal of Obesity, 39(8), 1325-1328

DOI: 10.1038/ijo.2015.35

Type: article