About
Research Fellow in Bioinformatics/Epigenetics within the Faculty of Medicine at the University of Southampton
Research
Research groups
Research interests
- My current research mainly involves working with DNA methylation data to identify epigenetic marks for periconceptional paternal smoking exposure across generations. This Epigenome Wide Association Study is part of the Rhinessa multicentre population project. My expertise includes integrating multi-omic data such as SNP, transcriptome, methylation and interactome (PPI) at the system level to understand the molecular mechanisms underlying the origins of complex diseases. In my former position, I worked on the epigenetic effects of Maternal Gestation Diabetes (GDM) using the UPBEAT Offspring data supported by Diabetes UK.
Research projects
Publications
15 publications
Page 1 of 2
Negusse Tadesse Kitaba, Toril Mørkve Østergaard, Marianne Lønnebotn, Simone Accordini, Francisco Gómez Real, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Vivi Schlünssen, Cecilie Svanes & John W. Holloway,
2025, Communications Biology, 8(1)
Type: article
Maggie P. Fu, Karlie Edwards, Erick I. Navarro-Delgado, Sarah M. Merrill, Negusse T. Kitaba, Chaini Konwar, Piush Mandhane, Elinor Simons, Padmaja Subbarao, Theo J. Moraes, John W. Holloway, Stuart E. Turvey & Michael S. Kobor,
2025
Type: other
Shaobo Li, Natalia Spitz, Akram Ghantous, Negusse Kitaba, Faisal I. Rezwan, S. Hasan Arshad & John W. Holloway,
2024, Communications Biology, 7(1)
Type: article
Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I. Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Sarah H. Watkins, Matthew Suderman, Francisco Gómez-Real, Vivi Schlünssen, Cecilie Svanes & John W. Holloway,
2023, Clinical Epigenetics, 15(1), 131
Type: article
Raquel Granell, John A. Curtin, Sadia Haider, Negusse Tadesse Kitaba, Sara A. Mathie, Lisa G. Gregory, Laura L. Yates, Mauro Tutino, Jenny Hankinson, Mauro Perretti, Judith M. Vonk, Hasan S. Arshad, Paul Cullinan, Sara Fontanella, Graham C. Roberts, Gerard H. Koppelman, Angela Simpson, Steve W Turner, Clare S. Murray, Clare M. Lloyd, John W. Holloway & Adnan Custovic,
2023, eLife, 12
DOI: 10.7554/eLife.84315
Type: article
R Granell, JA Curtin, S Haider, N Kitaba, S Mathie, L Gregory, LL Yates, M Tutino, J Hankinson, M Perretti, JM Vonk, SH Arshad, P Cullinan, S Fontanella, G Roberts, GH Koppelman, A Simpson, S Turner, CS Murray, C.M. Lloyd, JW Holloway & A Custovic,
2023
Type: other
N Kitaba, T. Knudsen, A. Johannessen, F. Rezwan, A. Malinovschi, A. Oudin, B. Benediktsdottir, D. Martino, F Callejas. González, L. Gómez, M. Holm, O. Jõgi, S. Shyamali Dharmage, S. Skulstad, F. Gómez-Real, V. Schlünssen, C. Svanes & J. Holloway,
2022, European Respiratory Journal, 60(66)
Type: conference
Nils O. Jõgi, Negusse Kitaba, Torgeir Storaas, Vivi Schlünssen, Kai Triebner, John W. Holloway, William G.c. Horsnell, Cecilie Svanes & Randi J. Bertelsen,
2022, Journal of Allergy and Clinical Immunology, 149(6), 1960-1969
Type: article
Mark Hanson, Robert Murray, Elie Antoun, Philip Titcombe, Sheila Barton, Negusse Kitaba, Cyrus Cooper, Hazel Inskip, Keith Godfrey, Graham Burdge, Karen Lillycrop, Pamela A Mahon, Julian Halcox & Elizabeth Ellins,
2021, International Journal of Obesity
Type: article
Robert Murray, Negusse Kitaba, Elie Antoun, Philip Titcombe, Sheila Barton, Cyrus Cooper, Hazel M. Inskip, Graham C. Burdge, Pamela A. Mahon, John Deanfield, Julian P. Halcox, Elizabeth A. Ellins, Jennifer Bryant, Charles Peebles, Karen Lillycrop, Keith M. Godfrey, Mark A. Hanson & Epi Gen Consortium,
2021, Hypertension, 78(3), 787-800
Type: article
Biography
Dr Negusse graduated from Addis Ababa University with a BSc in Biological Science and an MSc in Biodiversity. He completed his MSc in Bioinformatics at Cardiff University. He undertook research into gene regulation, pathway analysis and protein structure prediction to support drug discovery at the University of South Wales, graduating with a PhD in Computational Biology in 2015.
Dr Negusse has a keen interest in understanding how genetics and environmental interactions affect gene function and disease outcomes. He joined the University of Southampton, Faculty of Biological Science in 2017 where he investigated the effect of maternal gestational diabetes on the offspring epigenome. His current work in the Faculty of Medicine involves studying the transgenerational effect of paternal smoking.
Qualifications
PhD, Computational Biology, University of South Wales 2015
MSc, Bioinformatics, Cardiff University 2010
MSc, Biodiversity, Addis Ababa University 2006
BSc, Biological Science, Addis Ababa University 1999
Appointments held
Research Fellow in Bioinformatics/ Epigenetics: Rhinessa EWAS Project at Faculty of Medicine, University of Southampton (2020 -present)
Research Fellow in Epigenetics: UPBEAT Diabetes UK project at Faculty of Biological Science, University of Southampton (2017 to 2020)
Bioinformatics Scientist II PhoreMost Ltd, Cambridge (2017)
Prizes
- Fathers’ preconception smoking and offspring DNA methylation (2024)
- Transcriptomic Analysis of SARS-CoV-2 severity in a South African Cohort (2025)