About
Research Fellow in Bioinformatics/Epigenetics within the Faculty of Medicine at the University of Southampton
Research
Research groups
Member of:
Research interests
- My current research mainly involves working with DNA methylation data to identify epigenetic marks for periconceptional paternal smoking exposure across generations. This Epigenome Wide Association Study is part of the Rhinessa multicentre population project. My expertise includes integrating multi-omic data such as SNP, transcriptome, methylation and interactome (PPI) at the system level to understand the molecular mechanisms underlying the origins of complex diseases. In my former position, I worked on the epigenetic effects of Maternal Gestation Diabetes (GDM) using the UPBEAT Offspring data supported by Diabetes UK.
Publications
8 publications
Page 1 of 1
Nils O. Jõgi,
Torgeir Storaas,
Vivi Schlünssen,
Kai Triebner,
John W. Holloway,
William G.c. Horsnell,
Cecilie Svanes,
& Randi J. Bertelsen
, 2022
, Journal of Allergy and Clinical Immunology
, 149 (6) , 1960--1969
Type: article
Robert Murray,
Elie Antoun,
Cyrus Cooper,
Pamela A. Mahon,
John Deanfield,
Julian P. Halcox,
Elizabeth A. Ellins,
Jennifer Bryant,
Charles Peebles,
Mark A. Hanson,
& Epi Gen Consortium
, 2021
, Hypertension
, 78 (3) , 787--800
Type: article
Mark Hanson,
Robert Murray,
Elie Antoun,
Philip Titcombe,
Sheila Barton,
Pamela A Mahon,
Julian Halcox,
& Elizabeth Ellins
, 2021
, International Journal of Obesity
Type: article
Robert Murray,
Elie Antoun,
Sheila Barton,
Pamela A Mahon,
John Deanfield,
Julian P. Halcox,
Elizabeth A. Ellins,
Jennifer Bryant,
Charles Peebles,
& Mark Hanson
, 2021
, Hypertension
Type: article
Wenneke van Weelden,
Paul T. Seed,
Elie Antoun,
Karen Lillycrop,
Kathryn V. Dalrymple,
Agata Sobczyńska-Malefora,
Rebecca C. Painter,
Lucilla Poston,
Sara L. White,
& Angela Flynn
, 2021
, Journal of Developmental Origins of Health and Disease
Type: article
Elie Antoun,
Kathryn V. Dalrymple,
Sheila Barton,
A.C. Flynn,
Robert Murray,
Emma Garratt,
Paul T. Seed,
Sara L. White,
Mark Hanson,
L. Poston,
, 2021
, Epigenetics
Type: article
Elie Antoun,
Kathryn V. Dalrymple,
Emma S. Garratt,
Robert Murray,
Paul T. Seed,
Joanna D. Holbrook,
Michael S. Kobor,
David Ts Lin,
Julia L. Macisaac,
Sara L. White,
Lucilla Poston,
Keith M. Godfrey,
, 2020
, PLoS Medicine
, 17 (11)
Type: article
Luiza Borges Manna,
Georgia Papacleovoulou,
Flavia Flaviani,
Vanessa Formigo-Pataia,
Asaad Qadri,
Shadi Abu-Hayyeh,
Saraid Mcilvride,
Eugene Jansen,
Peter Dixon,
Jennifer Chambers,
Marta Vazquez Lopez,
Annika Wahlstroem,
Hanns-Ulrich Marschall,
Keith Godfrey,
& Catherine Williamson
, 2020
, Scientific Reports
, 10 (1)
Type: article
Biography
Dr Negusse graduated from Addis Ababa University with a BSc in Biological Science and an MSc in Biodiversity. He completed his MSc in Bioinformatics at Cardiff University. He undertook research into gene regulation, pathway analysis and protein structure prediction to support drug discovery at the University of South Wales, graduating with a PhD in Computational Biology in 2015.
Dr Negusse has a keen interest in understanding how genetics and environmental interactions affect gene function and disease outcomes. He joined the University of Southampton, Faculty of Biological Science in 2017 where he investigated the effect of maternal gestational diabetes on the offspring epigenome. His current work in the Faculty of Medicine involves studying the transgenerational effect of paternal smoking.
Qualifications
PhD, Computational Biology, University of South Wales 2015
MSc, Bioinformatics, Cardiff University 2010
MSc, Biodiversity, Addis Ababa University 2006
BSc, Biological Science, Addis Ababa University 1999
Appointments held
Research Fellow in Bioinformatics/ Epigenetics: Rhinessa EWAS Project at Faculty of Medicine, University of Southampton (2020 -present)
Research Fellow in Epigenetics: UPBEAT Diabetes UK project at Faculty of Biological Science, University of Southampton (2017 to 2020)
Bioinformatics Scientist II PhoreMost Ltd, Cambridge (2017)