Professor John Holloway

Professor John Holloway

PhD, FHEA

Associate V-P Interdisciplinary Research

Research interests

Human genetics
Epigenetics
Respiratory Disease

Accepting applications from PhD students.

Connect with John

Email: j.w.holloway@soton.ac.uk

Address: Southampton General Hospital, Tremona Road Shirley, SO16 6YD (View in Google Maps)

Google Scholar

ORCID

LinkedIn

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Research

Research groups

Member of:

Research interests

Human genetics
Epigenetics
Respiratory Disease
Allergy
Asthma

Research projects

Active projects

UNICORN (Unified Cohorts Research Network): Disaggregating asthma

Researchers:

Professor John Holloway

,

Professor Hasan Arshad ,

Professor Graham Roberts

Sponsor: Medical Research Council

Preconception environment and related epigenetic mechanisms in asthma and allergies

Researchers:

Professor John Holloway

Sponsor: The Research Council of Norway

Strategic Plan - Sustainability

Researchers:

Professor AbuBakr Bahaj ,

Doctor Ben Anderson ,

Professor Ian Williams ,

Professor Jane Falkingham ,

Professor Simon Kemp ,

Professor John Holloway

International Digital Health Partnership

Researchers:

Professor James Batchelor

,

Doctor Rebecca Glenny-Brown ,

Professor John Holloway ,

Professor Judith Holloway

Completed projects

Future Worlds Medicine: an Innovative Approach to Industrial Collaboration

Researchers:

Professor John Holloway

,

Professor Salim Khakoo

Sponsor: Medical Research Council

Does epigenetic methylation explain the gender-switch in adolescent asthma?

Researchers:

Professor John Holloway

,

Professor Hasan Arshad

Sponsor: National Institutes of Health

Genetics of Eczema in Kuwait

Researchers:

Professor John Holloway

Sponsor: Kuwait Foundation for the Advancement of Sciences

J Holloway: Trangenerational Epigenetic inheritance of allergy in a Multigenerational Cohort

Researchers:

Professor John Holloway

Sponsor: National Institutes of Health

Ageing Lungs in European Cohorts (ALEC Study)

Researchers:

Professor John Holloway

Sponsor: European Union

Effect of Prenatal Compounds on Adult Lung Function via Neonatal DNA-Methylation

Researchers:

Professor John Holloway

Sponsor: National Institutes of Health

Dr J Holloway Grant for Matthew Rose-Zerilli

Researchers:

Professor John Holloway

Sponsor: Aair Charity

Maths, Engineering and Life Sciences: making connections for precision medicine

Researchers:

Professor Deborah Mackay

,

Professor John Holloway ,

Professor Cyrus Cooper ,

Professor Peter Smith ,

Professor Benjamin Macarthur ,

Professor Jacek Brodzki

Sponsor: Medical Research Council

Variats of mast cell tryptase as markers and mediators of inflammation and tissue remodelling in asthma

Researchers:

Doctor Andrew Walls

,

Professor John Holloway

Sponsor: Medical Research Council

STELAR (Study Team for Early Life Asthma Research) consortium - Asthma e-lab and identification of novel endotypes of childhood asthma

Researchers:

Professor Hasan Arshad

,

Professor Graham Roberts ,

Professor John Holloway

Sponsor: Medical Research Council

Dr A Walls Asthma UK 06/026

Researchers:

Doctor Andrew Walls

,

Professor John Holloway

Sponsor: National Asthma Campaign

Protocadherin-1 expression

Researchers:

Professor John Holloway

Development and validation of quantitative pcr assays for lipid mediator pathways in human cells and tissues.

Researchers:

Professor Tony Sampson

,

Professor John Holloway

Sponsor: Aair Charity

Genetic alterations in p53 clonal patches in skin

Researchers:

Professor Eugene Healy

,

Professor John Holloway

Mutation burden of narrowband UVB

Researchers:

Professor Eugene Healy

,

Professor John Holloway ,

Doctor Matthew Rose-Zerilli

Biography

Professor John Holloway is Professor of Allergy and Respiratory Genetics in the Faculty of Medicine and also Associate Vice-President (interdisciplinary Research) at the University of Southampton.

John Holloway graduated with a B.Sc. in Biochemistry from Otago University, New Zealand in 1992. He undertook research based at both the University of Southampton and the Malaghan Institute (Wellington, New Zealand) into the genetic basis of asthma graduating with a Ph.D. from Otago University in 1997. In 1997 Professor Holloway returned to Southampton and together with Professor Stephen Holgate continued his research into the genetic basis of allergies and asthma. He now heads the Respiratory Genetics Group, based in the School of Human Development and Health in the Faculty of Medicine, undertaking research into the early life origins of asthma and other allergic and respiratory conditions with a particular focus on the interaction between the environment in early life and genetic and epigenetic factors in determining susceptibility. Much of the group's work builds on the unique Isle of Wight Birth Cohort led by Professor Hasan Arshad.

Professor Holloway was appointed to a personal chair in the Faculty of Medicine in 2011. As well as his on-going research, he contributes to Molecular Cell Biology teaching as part of the Bachelor of Medicine program. He has held appointments on the Scientific Advisory boards of Asthma UK, and was member of Council for the British Society of Allergy and Clinical Immunology (2009-2012) and vice-chair of the COST:BM1201 Developmental Origins of Chronic Respiratory Disease network (2012-2016). He has published over 150 papers field of allergy and respiratory genomics.

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