Professor Ronan McCarthy

Publications

29 publications

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Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

Nikol Kadeřábková, R Christopher D Furniss, Evgenia Maslova, Kathryn E Potter, Lara Eisaiankhongi, Patricia Bernal, Alain Filloux, Cristina Landeta, Diego Gonzalez, Ronan R McCarthy & Despoina AI Mavridou, 2025

DOI: 10.7554/eLife.91082

Type: other

Pseudomonas aeruginosa clinical isolates can encode plastic-degrading enzymes that allow survival on plastic and augment biofilm formation

Sophie A. Howard, Rubén de Dios, Evgenia Maslova, Antonis Myridakis, Thomas H. Miller & Ronan R. McCarthy, 2025, Cell Reports, 44(5)

DOI: 10.1016/j.celrep.2025.115650

Type: article

Engineering biology applications for environmental solutions: potential and challenges

David J. Lea-Smith, Francis Hassard, Frederic Coulon, Natalie Partridge, Louise Horsfall, Kyle D. J. Parker, Robert D. J. Smith, Ronan R. McCarthy, Boyd McKew, Tony Gutierrez, Vinod Kumar, Gabriella Dotro, Zhugen Yang, Thomas P. Curtis, Peter Golyshin, Sonia Heaven, Bruce Jefferson, Paul Jeffrey, Davey L. Jones, Kristell Le Corre Pidou, Yongqiang Liu, Tao Lyu, Cindy Smith, Alexander Yakunin, Yue Zhang & Natalio Krasnogor, 2025, Nature Communications, 16(1)

DOI: 10.1038/s41467-025-58492-0

Type: article

Saccharin disrupts bacterial cell envelope stability and interferes with DNA replication dynamics

Rubén de Dios, Kavita Gadar, Chris R Proctor, Evgenia Maslova, Jie Han, Mohamed A N Soliman, Dominika Krawiel, Emma L Dunbar, Bhupender Singh, Stelinda Peros, Tom Killelea, Anna-Luisa Warnke, Marius M Haugland, Edward L Bolt, Christian S Lentz, Christian J Rudolph & Ronan R McCarthy, 2025, EMBO Molecular Medicine, 17(5), 993-1017

DOI: 10.1038/s44321-025-00219-1

Type: article

Engineering biology approaches to modulate bacterial biofilms

Clodagh M. Carr, Lyuboslava G. Harkova & Ronan R. McCarthy, 2024, Trends in Biotechnology, 43(7), 1525-1527

DOI: 10.1016/j.tibtech.2024.11.002

Type: article

Cyclic AMP is a global virulence regulator governing inter and intrabacterial signalling in Acinetobacter baumannii

Lyuboslava G. Harkova, Mario F. Feldman, Rubén de Dios, Alejandro Rubio-Valle, Antonio J. Pérez-Pulido & Ronan R. McCarthy, 2024, PLoS Pathogens, 20(9)

DOI: 10.1371/journal.ppat.1012529

Type: article

Carbon source competition within the wound microenvironment can significantly influence infection progression

Evgenia Maslova, Lara EisaianKhongi, Petra Rigole, Tom Coenye & Ronan R. McCarthy, 2024, NPJ Biofilms and Microbiomes, 10(52)

DOI: 10.1038/s41522-024-00518-4

Type: article

Modulating biofilm can potentiate activity of novel plastic-degrading enzymes

Sophie A. Howard & Ronan R. McCarthy, 2023, NPJ Biofilms and Microbiomes, 9

DOI: 10.1038/s41522-023-00440-1

Type: article

Using next generation antimicrobials to target the mechanisms of infection

Kavita Gadar & Ronan R. McCarthy, 2023, NPJ Antimicrobials and Resistance, 1(11)

DOI: 10.1038/s44259-023-00011-6

Type: article

Disrupting iron homeostasis can potentiate colistin activity and overcome colistin resistance mechanisms in Gram-Negative Bacteria

Kavita Gadar, Rubén de Dios, Nikol Kadeřábková, Thomas A. K. Prescott, Despoina A. I. Mavridou & Ronan R. McCarthy, 2023, Communications Biology, 6

DOI: 10.1038/s42003-023-05302-2

Type: article

Biography

Ronan gained his Bachelor of Science in Genetics with first class honours from University College Cork, Ireland in 2010 and was awarded the title of College Scholar. In autumn 2010, Ronan was awarded an Irish Research Council PhD Scholarship to study novel biofilm inhibition strategies against the opportunistic pathogen Pseudomonas aeruginosa in the lab of Professor Fergal O’Gara. In 2014, Ronan joined the research group of Professor Alain Filloux at the MRC Centre for Bacteriology and Infection at Imperial College London. As a Postdoctoral Research Associate, Ronan interrogated the second messenger signalling cascades that govern the biofilm mode of growth in Pseudomonas aeruginosa and Agrobacterium tumefaciens. Following on from his time at Imperial College Ronan joined the Microbiology Department at the Animal and Plant Health Agency where he used host transcriptomics and pathway analysis to profile the host response to infection. He joined the Biosciences Division in Brunel University to continue his analysis of the regulatory networks that govern pathogenicity, antimicrobial resistance and biofilm formation in the Gram negative opportunistic pathogens Pseudomonas aeruginosa and Acinetobacter baumannii. In 2021, Ronan was awarded a BBSRC New Investigator Award to study the regulation of desiccation tolerance and biofilm formation in Acinetobacter baumannii and to identify compounds that could disrupt these survival mechanisms. He has also expanded into the field of biofilm engineering, using synthetic biology approaches to give control over bacterial biofilm formation and using these tools to tackle environmental challenges such as plastic waste. As a PI he has secured funding from the BBSRC, NC3Rs, Academy of Medical Sciences, Horizon 2020, British Society for Antimicrobial Chemotherapy, Innovate UK, NERC and the Medical Research Council. In 2025, he joined the University of Southampton to continue his work on understanding, harnessing and disrupting the regulatory pathways that govern biofilm formation.

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Publications

Biography