Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
K. Woods-Townsend, H. Leat, J. Bay, L. Bagust, H. Davey, D. Lovelock, A. Christodoulou, J. Griffiths, M. Grace, K. Godfrey, M. Hanson & H. Inskip,
2018, Journal of Developmental Origins of Health and Disease, 9(5), 475-480
Type: article
Tom P. Fleming, Adam J. Watkins, Miguel A. Velazquez, John C. Mathers, Andrew M. Prentice, Judith Stephenson, Mary Barker, Richard Saffery, Chittaranjan S. Yajnik, Judith J. Eckert, Mark A. Hanson, Terrence Forrester, Peter D. Gluckman & Keith M. Godfrey,
2018, Obstetrical and Gynecological Survey, 73(10), 555-557
Type: article
Phaik Quah, Ginanjar Syuhada, Lisa Fries, Mei Jun Chan, Hui Xian Lim, Jia Ying Toh, Ray Sugianto, Izzuddin M. Aris, Yung Seng Lee, Fabian Yap, Keith Godfrey, Peter D. Gluckman, Yap-Seng Chong, Lynette Pei-Chi Shek , Kok Hian Tan, Ciaran G Forde & Mary F.F. Chong,
2018, PLoS ONE, 13(9)
Type: article
Line Sletner, Pamela Mahon, Sarah R. Crozier, Hazel M. Inskip, Keith M. Godfrey, Scott Chiesa, Devina J. Bhowruth, Marietta Charakida, John Deanfield, Cyrus Cooper & Mark Hanson,
2018, Arteriosclerosis, Thrombosis, and Vascular Biology
Type: article
Anna Fogel, Lisa Fries, Keri McCrickerd, Ai Ting Goh, Phaik Ling Quah, Mei Jun Chan, Jia Ying Toh, Yap-Seng Chong, Kok Hian Tan, Fabian Yap, Lynette Shek, Michael J. Meaney, Birit Broekman, Yung Seng Lee, Keith Godfrey, Mary F.F. Chong & Ciaran G. Forde,
2018, Appetite, 126, 8-15
Type: article
Le Duc Huy Ta, Gaik Chin Yap, Carina Jing Xuan Tay, A S M Lim, C.H. Huang, C.W. Chu, P.F. De Sessions, Lynette P. Shek, Anne Goh, Hugo Van Bever, Oon Hoe Teoh, J.Y. Soh, Biju Thomas, M.B. Ramamurthy, Daniel Y.T. Goh, Christophe Lay, S.E. Soh, Yiong Chan, Seang-Mei Saw, Kenneth Kwek, Yap-Seng Chong, Keith Godfrey, Martin Lloyd Hibberd & Bee Wah Lee,
2018, Journal of Allergy and Clinical Immunology, 142(1), 86-95
Type: article
Matias Vieria, Shahina Begum, Paul T. Seed, Dania Badran, Annette Briley, Carolyn Anne Gill, Keith Godfrey, Deborah A. Lawlor, Scott M. Nelson, Nashita Patel, Naveed Sattar, Sara L. White, Lucilla Poston & Dharmintra Pasupathy,
2018, Pregnancy Hypertension An International Journal of Women s Cardiovascular Health, 13, 267-272
Type: article