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Research project

Investigating the role of PIP4K2B, nuclear phosphoinositides and TAF3 in transcription and genome organisation during myogenic differentiation

  • Lead researcher:
    Professor Nullin Divecha
  • Research funder:
    Biotechnology & Biological Sciences Research Council
  • Status:
    Not active

Staff

Lead researcher

Professor Nullin Divecha

Professor of Cellular Signalling

Research outputs

Mechanisms of SARS-CoV-2 inactivation using UVC laser radiation
George Devitt,
Peter B. Johnson,
Niall Hanrahan,
Simon I.R. Lane,
Magdalena C. Vidale,
Bhavwanti Sheth,
Joel D. Allen,
Maria V. Humbert,
Cosma M. Spalluto,
Rodolphe C. Herve,
Karl Staples,
Jonathan J. West,
Robert Forster,
Nullin Divecha,
Chris McCormick,
Max Crispin,
Nils Hempler,
Graeme P.A. Malcolm,
& Sumeet Mahajan
, 2023 , ACS Photonics
DOI: 10.1021/acsphotonics.3c00828
Type: article
PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1
A. Poli,
F.A. Pennacchio,
A. Ghisleni,
M. di Gennaro,
M. Lecacheur,
P. Nastaly,
M. Crestani,
F.M. Pramotton,
F. Iannelli,
G. Beznusenko,
A. A Mironov,
V. Panzetta,
S. Fusco,
B. Sheth,
D. Poulikakos,
A. Ferrari,
N. Gauthier,
P.A. Netti,
N. Divecha,
& P. Maiuri
, 2023 , Nature Communications , 14 (1)
DOI: 10.1038/s41467-023-37064-0
Type: article
Identification and optimization of a novel series of selective PIP5K inhibitors
D.M. Andrews,
S. Cartic,
S. Cosulich,
N. Divecha,
P. Faulder,
V. Flemington,
O. Kern,
J.G. Kettle,
E. MacDonald,
J. McKelvie,
K.G. Pike,
B. Roberts,
R. Rowlinson,
J.M. Agnos,
M. Stockley,
M.E. Swarbrick,
I. Treinies,
& M.J. Waring
, 2021 , Bioorganic & Medicinal Chemistry , 54
DOI: 10.1016/j.bmc.2021.116557
Type: article
Modulating phosphoinositide profiles as a roadmap for treatment in acute myeloid leukemia
S. Ratti,
C. Evangelisti,
S. Mongiorgi,
A. De Stefano,
A. Fazio,
F. Bonomini,
M.Y. Follo,
I. Faenza,
L. Manzoli,
B. Sheth,
M.C. Vidalle,
S.T. Kimber,
N. Divecha,
L. Cocco,
& R. Fiume
, 2021 , Frontiers in Oncology , 11
DOI: 10.3389/fonc.2021.678824
Type: article
PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity
Alessandro Poli,
Shidqiyyah Abdul-hamid,
Antonio Enrico Zaurito,
Francesca Campagnoli,
Valeria Bevilacqua,
Bhavwanti Sheth,
Roberta Fiume,
Massimiliano Pagani,
Sergio Abrignani,
& Nullin Divecha
, 2021 , Proceedings of the National Academy of Sciences , 118 (31) , e2010053118
DOI: 10.1073/pnas.2010053118
Type: article