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Professor Max Crispin

Professor Max Crispin

 DPhil, FRSB, FRSC, FHEA
Professorship of Glycobiology

Research interests

  • Viral Glycobiology
  • Therapeutic Antibodies

More research

Connect with Max

Email: max.crispin@soton.ac.uk

Address: B85, East Highfield Campus, University Road, SO17 1BJ (View in Google Maps)

Research

Research groups

Research interests

  • Viral Glycobiology
  • Therapeutic Antibodies

Current research

Viral Glycobiology: Our work assisting the development of an HIV vaccine is based on targeting the carbohydrate coat of HIV that shields the virus. We have shown that this shield is different from normal “self” carbohydrates and is remarkably constant despite huge variation in the underlying protein. We also study glycoproteins from a large range of other viruses including influenza and coronaviruses such as SARS-CoV-2.

Therapeutic Antibodies: Antibodies are incredibly versatile therapeutics and can exhibit both pro- and anti-inflammatory properties. For this reason, they are being applied to the treatment of conditions ranging from cancers to autoimmune disorders. Anti-cancer antibodies often rely on the recruitment of the immune system to cancerous cells through a constant region of the antibody termed the Fc region. We have structurally characterized how different glycans can impact on Fc structure and how they can be manipulated to fine-tune antibody effector functions. In addition, we are developing bispecific antibodies and a new approach for enhancing therapeutic antibodies against cancer that involves deactivating competing endogenous antibodies that can limit the potency of anti-cancer antibodies. We are very proud to be sponsored by Against Breast Cancer.

Research projects

Active projects

Researchers:
Professor Max Crispin
Sponsor: Bill & Melinda Gates Foundation
Researchers:
Professor Max Crispin
Sponsor: Against Breast Cancer
Researchers:
Professor Max Crispin
Sponsor: International AIDS Vaccine Initiative
Researchers: ,
Professor Max Crispin
Sponsor: Against Breast Cancer

Completed projects

Researchers:
Professor Max Crispin
,
Sponsor: National Institutes of Health
Researchers:
Professor Max Crispin
Sponsor: European Union
Researchers:
Professor Max Crispin
Sponsor: Bill & Melinda Gates Foundation
Researchers:
Professor Max Crispin
Sponsor: Bill & Melinda Gates Foundation
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