J Holloway: Trangenerational Epigenetic inheritance of allergy in a Multigenerational Cohort

Staff

Lead researcher

Professor John Holloway PhD, FHEA

Associate V-P Interdisciplinary Research

Research interests

Human genetics
Epigenetics
Respiratory Disease

Connect with John

Email: j.w.holloway@soton.ac.uk

Research outputs

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Latha Kadalayil,

Md. Zahangir Alam,

Cory Haley White,

Akram Ghantous,

Esther Walton,

Olena Gruzieva,

Simon Kebede Merid,

Ashish Kumar,

Ritu P. Roy,

Olivia Solomon,

Karen Huen,

Brenda Eskenazi,

Peter Rzehak,

Veit Grote,

Jean-paul Langhendries,

Elvira Verduci,

Natalia Ferre,

Darek Gruszfeld,

Lu Gao,

Weihua Guan,

Xuehuo Zeng,

Enrique F. Schisterman,

John F. Dou,

Kelly M. Bakulski,

Jason I. Feinberg,

Munawar Hussain Soomro,

Giancarlo Pesce,

Nour Baiz,

Elena Isaevska,

Michelle Plusquin,

Marina Vafeiadi,

Theano Roumeliotaki,

Sabine A.S. Langie,

Arnout Standaert,

Catherine Allard,

Patrice Perron,

Luigi Bouchard,

Evelien R. Van Meel,

Janine F. Felix,

Vincent W.V. Jaddoe,

Paul D. Yousefi,

Cecilia H. Ramlau-hansen,

Caroline L. Relton,

Elmar W. Tobi,

Anne P. Starling,

Ivana V. Yang,

Maria Llambrich,

Gillian Santorelli,

Johanna Lepeule,

Lucas A. Salas,

Mariona Bustamante,

Susan L. Ewart,

Hongmei Zhang,

Wilfried Karmaus,

Stefan Röder,

Ana Claudia Zenclussen,

Jianping Jin,

Wenche Nystad,

Christian M. Page,

Maria Magnus,

Dereje D. Jima,

Cathrine Hoyo,

Rachel L. Maguire,

Tuomas Kvist,

Darina Czamara,

Katri Räikkönen,

Tong Gong,

Vilhelmina Ullemar,

Sheryl L. Rifas-shiman,

Emily Oken,

Catarina Almqvist,

Robert Karlsson,

Jari Lahti,

Susan K. Murphy,

Siri E. Håberg,

Stephanie London,

Gunda Herberth,

Hasan Arshad,

Jordi Sunyer,

Regina Grazuleviciene,

Dana Dabelea,

Régine P.M. Steegers-Theunissen,

Ellen A. Nohr,

Thorkild I.A. Sørensen,

Liesbeth Duijts,

Marie-france Hivert,

Vera Nelen,

Maja Popovic,

Manolis Kogevinas,

Tim S. Nawrot,

Zdenko Herceg,

Isabella Annesi-maesano,

M. Daniele Fallin,

Edwina Yeung,

Carrie V. Breton,

Berthold Koletzko,

Nina Holland,

Joseph L. Wiemels,

Erik Melén,

Gemma C. Sharp,

Matt J. Silver,

Faisal I. Rezwan,

& John W. Holloway

, 2023 , Clinical Epigenetics , 15 (1)

DOI: 10.1186/s13148-023-01542-5

Type: article

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Olivia Solomon,

Karen Huen,

Paul Yousefi,

Leanne K. Küpers,

Juan R. Gonzalez,

Matthew Suderman,

Sarah E. Reese,

Christian M. Page,

Olena Gruzieva,

Peter Rzehak,

Lu Gao,

Kelly M. Bakulski,

Alexei Novoloaca,

Catherine Allard,

Irene Pappa,

Maria Llambrich,

Marta Vives,

Dereje D. Jima,

Tuomas Kvist,

Andrea A. Baccarelli,

Cory White,

Faisal I Rezwan,

Gemma C. Sharp,

Gwen Tindula,

Anna Bergström,

Veit Grote,

John F Dou,

Elena Isaevska,

Maria C. Magnus,

Eva Corpeleijn,

Patrice Perron,

Vincent W V Jaddoe,

Ellen A. Nohr,

Lea Maitre,

Maria Foraster,

Cathrine Hoyo,

Siri E. Håberg,

Jari Lahti,

Dawn L. DeMeo,

Hongmei Zhang,

Wilfried Karmaus,

Inger Kull,

Berthold Koletzko,

Jason I Feinberg,

Luigi Gagliardi,

Luigi Bouchard,

Cecilia Host Ramlau-Hansen,

Henning Tiemeier,

Gillian Santorelli,

Rachel L. Maguire,

Darina Czamara,

Augusto A. Litonjua,

Jean-Paul Langhendries,

Michelle Plusquin,

Johanna Lepeule,

Elisabeth B. Binder,

Elvira Verduci,

Terence Dwyer,

Angel Carracedo,

Natalia Ferre,

Brenda Eskenazi,

Manolis Kogevinas,

Tim S. Nawrot,

Monica Cheng Munthe-Kaas,

Zdenko Herceg,

Caroline L. Relton,

Erik Melen,

Dariusz Gruszfeld,

Carrie Breton,

M D Fallin,

Akram Ghantous,

Wenche Nystad,

Barbara Heude,

Harold Snieder,

Marie-France Hivert,

Janine F. Felix,

Thorkild I. A. Sørensen,

Mariona Bustamante,

Susan K. Murphy,

Katri Raikkonen,

Emily Oken,

John Holloway,

Syed Arshad,

Stephanie London,

& Nina Holland

, 2022 , Mutation Research - Reviews in Mutation Research , 789

DOI: 10.1016/j.mrrev.2022.108415

Type: review

Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization

Adrian Chan,

William Terry,

Hongmei Zhang,

Wilfried Karmaus,

Susan Ewart,

John W Holloway,

Graham Roberts,

Ramesh Kurukulaaratchy,

& Syed Hasan Arshad

, 2018 , Clinical & Experimental Allergy , 48 (2) , 147--155

DOI: 10.1111/cea.13077

Type: article

The role of DNA methylation in type 2 diabetes aetiology – using genotype as a causal anchor

Hannah Elliot,

Hashem Shihab,

Gabrielle A. Lockett,

John Holloway,

Allan F. McRae,

George Davey-Smith,

Susan M. Ring,

Tom R. Gaunt,

& Caroline L. Relton

, 2017 , Diabetes , 66 (6) , 1713--1722

DOI: 10.2337/db16-0874

Type: article

Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy

Ali H Ziyab,

Susan Ewart,

Gabrielle A Lockett,

Hongmei Zhang,

Syed Arshad,

John W Holloway,

& Wilfried Karmaus

, 2017 , Clinical & Experimental Allergy , 47 (9) , 1185--1192

DOI: 10.1111/cea.12956

Type: article