Research project

J Holloway: Trangenerational Epigenetic inheritance of allergy in a Multigenerational Cohort

Lead researchers:

Professor John Holloway
Research funder:

National Institutes of Health
Status:

Not active

Staff

Lead researchers

Professor John Holloway PhD, FHEA, FERS

Associate VP Interdisciplinary Research

Research interests

Human genetics
Epigenetics
Respiratory Disease

Connect with John

Email: J.W.Holloway@soton.ac.uk

Research outputs

The role of DNA methylation in type 2 diabetes aetiology – using genotype as a causal anchor

Hannah Elliot, Hashem Shihab, Gabrielle A. Lockett, John Holloway, Allan F. McRae, George Davey-Smith, Susan M. Ring, Tom R. Gaunt & Caroline L. Relton, 2017, Diabetes, 66(6), 1713-1722

DOI: 10.2337/db16-0874

Type: article

Multi-generational cohorts in asthma and allergy

Hasan Arshad, Wilfried Karmaus, Hongmei Zhang & John W. Holloway, 2017, Journal of Allergy and Clinical Immunology, 139(2), 415-421

DOI: 10.1016/j.jaci.2016.12.002

Type: article

Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence

Vimala Devi Janjanam, Nandini Mukherjee, Gabrielle A. Lockett, Faisal I. Rezwan, Ramesh Kurukulaaratchy, Frances Mitchell, Hongmei Zhang, Hasan Arshad, John Holloway & Wilfried Karmaus, 2016, Vaccine, 34(51), 6493-6501

DOI: 10.1016/j.vaccine.2016.10.068

Type: article

Is there an association between season of birth and blood DNA methylation in adulthood?

P-A. Dugué, Y. M. Geurts, R. L. Milne, G.A. Lockett, H. Zhang, W. Karmaus & J. W. Holloway, 2016, Allergy, 71(10), 1501-1504

DOI: 10.1111/all.12949

Type: article

Evaluating the efficacy of breastfeeding guidelines on long-term outcomes for allergic disease

Victoria Bion, Gabrielle A. Lockett, Nelís Soto-Ramírez, Hongmei Zhang, Carina Venter, Wilfried Karmaus, John W. Holloway & S. Hasan Arshad, 2016, Allergy, 71(5), 661-670

DOI: 10.1111/all.12833

Type: article

DNA methylation and genetic polymorphisms of the Leptin gene interact to influence lung function outcomes and asthma at 18 years of age

Nadini Mukherjee, Gabrielle A. Lockett, Simon K. Merid, Eric Melén, Göran Pershagen, John Holloway, Syed Hasan Arshad, Susan Ewart, Hongmei Zhang & Wilfried Karmaus, 2016, International Journal of Molecular Epidemiology and Genetics, 7(1), 1-17

Type: article

DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection

Todd M. Everson, Genevieve Lyons, Hongmei Zhang, Nelís Soto-Ramírez, Gabrielle A. Lockett, Veeresh, Keshirajagowda Patil, Simon K. Merid, Cilla Sӧderhӓll, Erik Melén, John W. Holloway, S. Hasan Arshad & Wilfried Karmaus, 2015, Genome Medicine, 7(1), 89

DOI: 10.1186/s13073-015-0213-8

Type: article