Project overview
We propose that miRNAs play a critical role in the regulation of skeletal stem cell fate and function. We will determine the role of miRNAs in the maintenance of stem phenotype or enhancement of bone stem cell differentiation and mechanisms involved including cytoskeletal or epigenetic changes. We have recently shown that defined nanotopographies are capable of robustly regulating SSC fate in the absence of chemical cues. We will therefore use custom designed nanotopographies to control SSC phenotype (for instance, to induce osteogenesis or maintain SSC numbers) and examine how miRNAs affect stem cell responses through modulation of epigenetic, biochemical and biomechanical processes. This study will facilitate our understanding of the mechanisms involved in the regulation of skeletal stem cell fate and function.
Research outputs
Shona J. Waddell,
María C. de Andrés,
Penelope M. Tsimbouri,
Enateri V. Alakpa,
Maggie Cusack,
Matthew J. Dalby,
, 2018
, Journal of Tissue Engineering
, 9 , 1--13
Type: article
Catarina Costa Moura,
Stuart A. Lanham,
Tual Montfort,
Konstantinos N. Bourdakos,
, 2018
, Integrative Biology
DOI: 10.1039/C8IB00050F
Type: article
Mohamed Mousa,
, 2018
, Biomaterials
, 159 , 204--214
Type: review
Vitali Goriainov,
Gry Hulsart-Billstrom,
Terje Sjostrom,
Bo Su,
, 2018
, Frontiers in Bioengineering and Biotechnology
, 6 (APR) , 1--16
Type: article
Daniel Tang,
Liang-Yo Yang,
Keng-Liang Ou,
, 2017
, Frontiers in Bioengineering and Biotechnology
, 5 (77)
Type: article