Project overview
We propose that miRNAs play a critical role in the regulation of skeletal stem cell fate and function. We will determine the role of miRNAs in the maintenance of stem phenotype or enhancement of bone stem cell differentiation and mechanisms involved including cytoskeletal or epigenetic changes. We have recently shown that defined nanotopographies are capable of robustly regulating SSC fate in the absence of chemical cues. We will therefore use custom designed nanotopographies to control SSC phenotype (for instance, to induce osteogenesis or maintain SSC numbers) and examine how miRNAs affect stem cell responses through modulation of epigenetic, biochemical and biomechanical processes. This study will facilitate our understanding of the mechanisms involved in the regulation of skeletal stem cell fate and function.
Research outputs
Patricia Goggin,
Elaine, Ming Li Ho,
Helmut Gnaegi,
Stuart Searle,
& Philipp Schneider
, 2020
, Bone
, 131
Type: review
Lucas Sebastian Spitzhorn,
Matthias Megges,
Wasco Wruck,
Md Shaifur Rahman,
Jörg Otte,
Özer Degistirici,
Roland Meisel,
Rüdiger Volker Sorg,
& James Adjaye
, 2019
, Stem Cell Research & Therapy
, 10 (1)
Type: article
Cesar Roberto Alcala Orozco,
Khoon Lim,
Michael Glinka,
Isha Mutreja,
Tim Woodfield,
, 2019
, Biofabrication
, 11 (3)
Type: article
Catarina Moura,
Konstantinos Bourdakos,
, 2019
, Scientific Reports
, 9 (1) , 1--9
Type: article
Howard, Clementi Tribe,
Neil Jacobs,
N. Hancock,
Amir Qureshi,
& D.G. Dunlop
, 2018
, Regenerative Medicine
, 13 (4)
Type: article