Research project

S Khakoo: Using MHC Class l Peptides to modulate NK cell activity, as a basis for immunotherapy

Lead researchers:

Professor Salim Khakoo
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researchers

Professor Salim Khakoo

Professor of Hepatology

Connect with Salim

Email: S.I.Khakoo@soton.ac.uk

Research outputs

IL-12 and IL-15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells

Theresa Hydes, Angela Noll, Gabriela Salinas-Riester, Mohammed Abuhilal, Thomas Armstrong, Zaed Hamady, John Primrose, Arjun Takhar, Lutz Walter & Salim I. Khakoo, 2017, Immunity, Inflammation and Disease, 6(1), 34-46

DOI: 10.1002/iid3.190

Type: article

KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C

Mohammed M. Naiyer, Sorcha A. Cassidy, Andrea Magri, Vanessa Cowton, Kevin Chen, Salah Mansour, Hariklia Kranidioti, Berenice Mbiribindi , Pauline Rettman, Scott Harris, Liam J. Fanning, Arend Mulder, Franz H.J. Claas, Andrew D. Davidson, Arvind H. Patel, Marco A. Purbhoo & Salim I. Khakoo, 2017, Science immunology, 2(15)

DOI: 10.1126/sciimmunol.aal5296

Type: article

HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs

Christine Thöns, Tina Senff, Theresa J. Hydes, Angela R. Manser, Falko M. Heinemann, Andreas Heinold, Martin Heilmann, Arthur Y. Kim, Markus Uhrberg, Norbert Scherbaum, Georg M. Lauer, Salim I. Khakoo & Jörg Timm, 2017, Journal of Hepatology, 67(3), 462-470

DOI: 10.1016/j.jhep.2017.03.040

Type: article

The interaction of genetic determinants in the outcome of HCV infection: evidence for discrete immunological pathways

T.J. Hydes, B. Moesker, J.A. Traherne, S. Ashraf, G.J. Alexander, B.D. Dimitrov, C.H. Woelk, J. Trowsdale & S.I. Khakoo, 2015, Tissue Antigens, 86(4), 267-275

DOI: 10.1111/tan.12650

Type: article

NK cells: tuned by peptide?

J. Das & S.I. Khakoo, 2015, Immunological Reviews, 267(1), 214-227

DOI: 10.1111/imr.12315

Type: article

Innate and adaptive genetic pathways in HCV infection

R. Buchanan, T. Hydes & S.I. Khakoo, 2015, Tissue Antigens, 85(4), 231-240

DOI: 10.1111/tan.12540

Type: article

Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population

Theresa Hydes, Mohammed Abu Hilal, Thomas Armstrong, John Primrose, Arjun Takhar & Salim Khakoo, 2015, The Lancet, 385(Supplement 1), S45

DOI: 10.1016/S0140-6736(15)60360-9

Type: conference