Research project

S Khakoo: Using MHC Class l Peptides to modulate NK cell activity, as a basis for immunotherapy

Lead researcher:

Professor Salim Khakoo
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researcher

Professor Salim Khakoo

Professor of Hepatology

Connect with Salim

Email: s.i.khakoo@soton.ac.uk

Research outputs

Selinexor enhances NK cell activation against malignant B cells via downregulation of HLA-E

Jack, Graham Fisher,

Salim Khakoo,

Mark Cragg,

Francesco Forconi,

Peter Johnson,

Amber Doyle,

christopher Walker,

yosef landesman,

& Matthew Blunt

, 2021 , Frontiers in Oncology

DOI: 10.3389/fonc.2021.785635

Type: article

A peptide: MHC based DNA vaccination strategy to activate natural killer cells by targeting killer cell immunoglobulin-like receptors.

Salim Khakoo,

Pauline E Rettman,

Matthew Blunt,

Rebecca Fulton,

Andres Vallejo Pulido,

Leidy Bastidas Legarda,

Laura Espana-Serrano,

Marta Polak,

Aymen Al-Shamkhani,

& Christelle Retiere

, 2021 , Journal for Immunotherapy of Cancer , 9 (5)

DOI: 10.1136/jitc-2020-001912

Type: article

Constitutive activation of natural killer cells in Primary Biliary Cholangitis

Theresa J. Hydes,

Matthew D. Blunt,

Jennifer Naftel,

Andres F. Vallejo,

Grégory Seumois,

Alice Wang,

Pandurangan Vijayanand,

Marta E. Polak,

& Salim I. Khakoo

, 2019 , Frontiers in Immunology , 10 , 1--12

DOI: 10.3389/fimmu.2019.02633

Type: article

A novel antibody combination to identify KIR2DS2(high) NK cells in KIR2DL3/L2/S2 heterozygous donors

Matthew Blunt,

Pauline Rettman,

Leidy, Yamile Bastidas Legarda,

Rebecca Fulton,

Valentino Capizzuto,

Mohammed M Naiyer,

James A. Traherne ,

& Salim Khakoo

, 2019 , HLA , 93 (1) , 32--35

DOI: 10.1111/tan.13413

Type: article

Inhibitory killer cell immunoglobulin-like receptors strengthen CD8⁺ T cell-mediated control of HIV-1, HCV, and HTLV-1

Lies Boelen,

Bisrat Debebe,

Marcos Silveira,

Arafa Salam,

Julia Makinde,

Chrissy H. Roberts,

Eddie C.Y. Wang,

John Frater,

Jill Gilmour,

Katie Twigger,

Kristin Ladell,

Kelly L. Miners,

Jyothi Jayaraman,

James A. Traherne,

David A. Price,

Ying Qi,

Maureen P. Martin,

Derek C. Macallan,

Chloe L. Thio,

Jacquie Astemborski,

Gregory Kirk,

Sharyne M. Donfield,

Susan Buchbinder,

Salim I. Khakoo,

James J. Goedert,

John Trowsdale,

Mary Carrington,

Simon Kollnberger,

& Becca Asquith

, 2018 , Science immunology , 3 (29)

DOI: 10.1126/sciimmunol.aao2892

Type: article