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The University of Southampton
Southampton Clinical Trials Unit

Dr Andrew Davies BSc (Hons), BM (Hons), MRCP, PhD

Honorary Senior Lecturer and Consultant in Medical Oncology

Dr Andrew Davies's photo

Dr Andrew Davies is Honorary Senior Lecturer and Consultant in Medical Oncology within Medicine at the University of Southampton.

Dr Davies is Senior Lecturer in Medical Oncology in the Cancer Sciences Division at the University of Southampton School of Medicine. He graduated in medicine with honours from the University of Southampton having also gained a first class Bachelor of Science degree. He went on to train in Medical Oncology at St Bartholomew’s Hospital in London, and as a Cancer Research UK Clinical Fellow undertook a PhD examining the molecular mechanisms underlying transformation of follicular lymphoma to more aggressive histological sub-types.
Dr Davies specialises in the treatment of malignant lymphoma and the use of high-dose chemotherapy. He has a particular interest in the investigation of monoclonal antibody containing therapies applied to lymphoma and in the translation of biomarkers and novel therapies to the clinical arena. He is the principle investigator on a number of early phase clinical studies.

Dr Davies has authored or co-authored numerous publications including those published in The Lancet Oncology, the Journal of Clinical Oncology, Blood and Haematologica.

Qualifications

BSc (First Class Hons) 1992 University of Southampton
BM (Hons) 1993 University of Southampton
MRCP (1997) Royal College of Physicians (London)
CCT in Medical Oncology (2007) PMETB
PhD (2007) University of London

Appointments held

Jan 2008 to present:
Cancer Research UK Senior Lecturer and Honorary Consultant in Medical Oncology, University of Southampton

April 2005 – Jan 2008
Specialist Registrar in Medical Oncology
St Bartholomew’s Hospital, London

April 2001-March 2008
Cancer research UK Clinical Fellow and Honorary Lecturer in Medical Oncology
Barts and The London School of Medicine and Dentistry, University of London

Jan 2000 – March 2001
Specialist Registrar in Medical Oncology
St Bartholomew’s Hospital, London

Research interests

My major research interest is in the application translational studies and novel therapeutic approaches for patients with malignant lymphoma

REMoDL-B: A randomised evaluation of molecular targeted therapy in diffuse large B-cell lymphoma with bortezomib (Peter Johnson). Phase III NCRI first line study in DLBCL (n=940).

Gallium: An International phase III study evaluating the benefit of GA101 plus chemotherapy compared with rituximab plus chemotherapy in patients with advanced stage follicular lymphoma (n=1400). This will be the largest study ever conducted in this patient population and is a collaboration between the UK NCRI group, Roche and the German Low Grade Study Group.

IELSG primary mediastinal B-cell lymphoma study: An international randomised phase III comparative study assessing the role of involved mediastinal radiotherapy after rituximab containing chemotherapy and following PET assessment.

Anti CD19 DI-B4: Through the Cancer Research UK New Agents Committee (NAC) this will be a first in man phase I trial of a novel anti CD-19 monoclonal antibody in B-cell lymphoma and CLL

Semprus PICC line study: Working with a biotech start-up company from MIT along with the Division of Infection, Inflammation and Immunity, The School of Engineering and PHLS, a first in man study of a novel coated indwelling intravenous catheters is funded and will include novel microbiological/physical endpoints.

In addition, I am a co-Investigator, local PI, and member of the Trials Management Group of a number of CRUK funded studies

Southampton LLR TAP Centre: I have led (PI) a successful grant bid for Southampton to become a Leukaemia and Lymphoma Research Therapies Acceleration Programme Centre, which will provide infrastructure for delivery of more early phase clinical trails in haematological malignancies.

Research group

Cancer Sciences

Affiliate research group

Cancer Sciences Research group

University of Southampton

Academic Clinical Lead for Medical Oncology
Lead for Early Phase Trails Unit

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Articles

Book Chapters

  • Gallagher, C. J., Lister, T. A. A., Johnson, M. J., & Davies, A. J. (2009). Malignant disease. In P. Kumar, & M. L. Clark (Eds.), Kumar and Clark's Clinical Medicine. 7th Edition UK: Elsevier Health Science.
  • Davies, A. J., & Lister, T. A. (2004). New therapies for B-cell non-Hodgkin's lymphoma. In A. Miles, R. Marcus, & D. Cunningham (Eds.), The Effective Management of Non-Hodgkins Lymphoma (UK Key Advances in Clinical Practice). London, UK: Aesculapius Medical Press.
  • Davies, A. J., & Rohatiner, A. Z. S. (2003). Prevention and management of tumour lysis in adults. In A. Rohatiner, A. Miles, & R. Pinkerton (Eds.), The Effective Prevention and Management of Common Complications of Induction Chemotherapy in Hamatological Malignany (UK Key Advances in Clinical Practice). London, UK: Aesculapius Medical Press.
  • Davies, A. J., & Rohatiner, A. Z. R. (2002). The general management of the patient with leukaemia. In E. S. Henderson, T. A. Lister, & M. F. Greaves (Eds.), Leukemia (7th Edition Elseiver Science). London, GB: Saunders.
  • Rohatiner, A. Z., Davies, A. J., Montoto, S., & Lister, T. A. (1998). Chapter 19 - Follicular lymphoma. In G. Canellos, T. A. Lister, & B. Young (Eds.), The Lymphomas (pp. 348-373). USA: W B Saunders Company. DOI: 10.1016/B978-072160081-9.50023-6

Reviews

Medical Student Tutor

Medical Student and Foundation Year Selector

Educational Supervisor for numerous Postgraduate Medics

Dr Andrew Davies
Mail Point 131,
Southampton General Hospital,
Tremona Road, Southampton,
Hampshire,
SO16 6YD

Room Number: SGH/CCI/MP824

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