Simon Crabb

Research

Research groups

Member of:

Research interests

Bladder cancer
Prostate cancer
Predictive biomarkers
Precision medicine
Early phase cancer clinical trials

Research projects

Active projects

An Open Label Single Arm Phase II Study of Atezolizumab in patients with non-TCC of the bladder and urothelial tract

Researchers:

Professor Simon Crabb

Professor Andy Davies

Sponsor: Cancer Research UK

A multicentre randomised controlled trial (RCT) of a uro-oncology clinical nurse specialist (CNS) team delivered cognitive behavioural therapy (CBT) intervention to reduce the impact of hot flush and night sweat (HFNS) symptoms in men with prostate cancer

Researchers:

Professor Simon Crabb

Professor Alison Richardson

Sponsor: National Institute of Health and Care Research

ELECTRA (intraoperativE eLECtron radioTherapy in Rectal cAncer): A single-blinded feasibility study of intraoperative electron beam radiotherapy in patients with locally advanced or locally recurrent rectal cancer

Researchers:

Professor Alex Mirnezami

Professor Simon Crabb ,

Professor Joanne Lord

Cancer Research UK Southampton Centre - Non-Clinical Training Award

Researchers:

Professor Peter Johnson

Professor Diana Eccles ,

Professor Tim Underwood ,

Professor Stephen Beers ,

Professor Jon Strefford ,

Doctor Jeremy Blaydes ,

Professor Edd James ,

Professor John Primrose ,

Professor Gareth Thomas ,

Professor Ramsey Cutress ,

Professor Francesco Forconi ,

Professor Freda Stevenson ,

Professor Alex Mirnezami ,

Professor Mark Cragg ,

Professor Aymen Al-Shamkhani ,

Professor Anneke Lucassen ,

Professor Simon Crabb ,

Doctor Juliet Gray ,

Doctor Sean Lim ,

Doctor Ellen Copson ,

Professor Graham Packham

Sponsor: Cancer Research UK

CRAIN: A phase 1b clinical trial with dose escalation and dose expansion phases of ASTX660 in combination with standard radical radiotherapy in cervical cancer with chemoradiation

Researchers:

Professor Gareth Griffiths

Professor Simon Crabb

Sponsor: Cancer Research UK

CTU - CCTG- Crabb - A RANDOMIZED PHASE II TRIAL ASSESSING TRIMODALITY THERAPY WITH OR WITHOUT ADJUVANT DURVALUMAB TO TREAT PATIENTS WITH MUSCLE-INVASIVE BLADDER CANCER

Researchers:

Professor Gareth Griffiths

Professor Simon Crabb

Sponsor: Queen's University at Kingston

CRAIN: A Phase 1b Clinical Trial With Dose Escalation And Dose Expansion Phases Of ASTX660 In Combination With Standard Radical Radiotherapy In Cervical Cancer With Chemoradiation

Researchers:

Professor Gareth Griffiths

Professor Simon Crabb

Sponsor: Astex Pharmaceuticals, Inc.

Completed projects

S Crabb - CRUK - C9317/A20783 - Therapeutic inhibition of the histone demethylase LSD1 to attenuate androgen receptor signalling in prostate cancer that is resistant to new generation AR antagonists

Researchers:

Professor Simon Crabb

Professor Graham Packham

Sponsor: Cancer Research UK

S Crabb: Alliance with Plexxikon: A phase Ib/IIa trial to combine the CSF1 receptor inhibitor PLX3397 with the new generation AR antagonist enzalutamide in metastatic castration resistant prostate cancer

Researchers:

Professor Simon Crabb

Professor Gareth Griffiths

Sponsor: Cancer Research UK

SAKK 08/11 Trial - Collaboration Agreement w UHS

Researchers:

Professor Simon Crabb

Sponsor: SAKK - Swiss Group for Clinical Cancer Research

Hayden Wessex R05 LSD1 Inhibitors for prostate cancer

Researchers:

Professor Simon Crabb

Professor Ramsey Cutress ,

Professor Graham Packham

Sponsor: Wessex Medical Research

Dr S Crabb: M 16: Innovation Grant: HDAC Inhibitors and Breast Cancer

Researchers:

Professor Simon Crabb

Sponsor: Wessex Medical Research

S Crabb-Astex Pharmaceuticals Inc - SGI-110-EP10

Researchers:

Professor Simon Crabb

Professor Gareth Griffiths

Sponsor: Astex Pharmaceuticals, Inc.

S Crabb PCUK Therapeutic inhibition of the histone demethylase

Researchers:

Professor Simon Crabb

Professor Graham Packham

Sponsor: Prostate Cancer UK

Researchers:

Professor Simon Crabb

Professor Gareth Griffiths

Sponsor: Plexxikon Inc

S Crabb - CRUKD/16/004 SPIRE -C9317/A19903

Researchers:

Professor Simon Crabb

Professor Gareth Griffiths

Sponsor: Cancer Research UK

Cancer Research UK Southampton Centre - Clinical Training Award

Researchers:

Professor Peter Johnson

Professor Diana Eccles ,

Professor Stephen Beers ,

Professor Tim Underwood ,

Professor Jon Strefford ,

Doctor Jeremy Blaydes ,

Professor Edd James ,

Professor John Primrose ,

Professor Gareth Thomas ,

Professor Ramsey Cutress ,

Professor Francesco Forconi ,

Professor Freda Stevenson ,

Professor Alex Mirnezami ,

Professor Mark Cragg ,

Professor Aymen Al-Shamkhani ,

Professor Anneke Lucassen ,

Professor Simon Crabb ,

Doctor Juliet Gray ,

Doctor Sean Lim ,

Doctor Ellen Copson ,

Professor Graham Packham

Sponsor: Cancer Research UK

Cancer Research UK Southampton Centre

Researchers:

Professor Peter Johnson

Professor Diana Eccles ,

Professor Tim Underwood ,

Professor Stephen Beers ,

Professor Jon Strefford ,

Doctor Jeremy Blaydes ,

Professor Edd James ,

Professor John Primrose ,

Professor Gareth Thomas ,

Professor Ramsey Cutress ,

Professor Francesco Forconi ,

Professor Freda Stevenson ,

Professor Alex Mirnezami ,

Professor Mark Cragg ,

Professor Aymen Al-Shamkhani ,

Professor Anneke Lucassen ,

Professor Simon Crabb ,

Doctor Juliet Gray ,

Doctor Sean Lim ,

Doctor Ellen Copson ,

Professor Graham Packham

Sponsor: Cancer Research UK

External roles and responsibilities

Name: Cancer Research UK Experimental Medicine Expert Review Panel (External organisation)

Role: Member

Year: 2015 - 2021

Name: National Cancer Research Institute Bladder and Renal Group (External organisation)

Role: Member

Year: 2012 - 2021

Name: National Cancer Research Institute Prostate Group (External organisation)

Role: Member

Year: 2012 - 2021

Name: National Cancer Research Institute Advanced Bladder Cancer Subgroup (External organisation)

Role: Chair

Year: 2014 - 2018

Name: Bladder Cancer Genomics England Clinical Interpretation Partnership (External organisation)

Role: Chair

Year: 2016 -

Name: British Association for Cancer Research Executive Committee (External organisation)

Role: Member

Year: 2012 - 2015

Name: Experimental Cancer Medicine Centre (External organisation)

Role: Member

Year: 2015 - 2020

Name: International Rare Cancers Initiative Genitourinary Cancers Group (External organisation)

Role: Member

Year: 2018 -

Professor Simon Crabb

Research interests

Connect with Simon

Research

Research groups

Research interests

Research projects

Active projects

Completed projects

Publications

External roles and responsibilities

Biography