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Professor Gareth Griffiths

Professor Gareth Griffiths

Director SCTU & Prof of Clinical Trials

Research interests

Gareth Griffiths is Professor of Clinical Trials and directs our Southampton Clinical Trials Unit. He works with clinicians, research groups and other scientists in the development of important clinical trials and other well-designed studies that aim to improve the treatment of a range of cancers and other diseases, and early diagnosis of cancer.
His works spans the different phases of clinical trials, from small dose finding and safety studies involving a handful of patients to larger trials of hundreds of patients looking at whether the treatments are better than the current standard treatments. His early diagnosis studies include thousands of patients looking at new ways to detect cancer early. Ultimately, these studies could help change the way that patients are treated for the better, by creating the evidence so as the new treatments becomes the standard of care for future patients treated in the NHS.
Phase I-III clinical trials

Connect with Gareth

Email: G.O.Griffiths@soton.ac.uk

Tel: +44 23 8120 5154

ORCID

Research

Research groups

Member of:

Research interests

Gareth Griffiths is Professor of Clinical Trials and directs our Southampton Clinical Trials Unit. He works with clinicians, research groups and other scientists in the development of important clinical trials and other well-designed studies that aim to improve the treatment of a range of cancers and other diseases, and early diagnosis of cancer.
His works spans the different phases of clinical trials, from small dose finding and safety studies involving a handful of patients to larger trials of hundreds of patients looking at whether the treatments are better than the current standard treatments. His early diagnosis studies include thousands of patients looking at new ways to detect cancer early. Ultimately, these studies could help change the way that patients are treated for the better, by creating the evidence so as the new treatments becomes the standard of care for future patients treated in the NHS.
Phase I-III clinical trials
Early Diagnosis studies
Trial Methodology

Research projects

Active projects

AGILE: Seamless Phase I/Iia Platform for the Rapid Evaluation of Candidates for COVID-19 treatment

Researchers:

Professor Gareth Griffiths

Professor Saul Faust

Sponsor: Medical Research Council

Optimizing MATrix as remission induction treatment for newly diagnosed primary CNS Lymphoma – a randomized phase III trial (OPTIMATE trial)

Researchers:

Professor Gareth Griffiths

Professor Andy Davies

Sponsor: Cancer Research UK

Dr Andrew Davies - IELSG 37

Researchers:

Professor Gareth Griffiths

Sponsor: International Extranodal Lymphoma Study Group

CRAIN: A phase 1b clinical trial with dose escalation and dose expansion phases of ASTX660 in combination with standard radical radiotherapy in cervical cancer with chemoradiation

Researchers:

Professor Gareth Griffiths

Professor Simon Crabb

Sponsor: Cancer Research UK

CTU - CCTG- Crabb - A RANDOMIZED PHASE II TRIAL ASSESSING TRIMODALITY THERAPY WITH OR WITHOUT ADJUVANT DURVALUMAB TO TREAT PATIENTS WITH MUSCLE-INVASIVE BLADDER CANCER

Researchers:

Professor Gareth Griffiths

Professor Simon Crabb

Sponsor: Queen's University at Kingston

CRUK Core: Southampton Clinical Trials Unit

Researchers:

Professor Gareth Griffiths

Professor Simon Crabb

Sponsor: Cancer Research UK

DETECTION2 feasibility: A feasibility trial to assess recruitment rates and ctDNA reporting times for patients with resected stage IIB/IIC/IIIA melanoma.

Researchers:

Professor Gareth Griffiths

SELECTMeso1: A phase II trial of BI907828 in patients with relapsed mesothelioma harbouring CDKN2A loss

Researchers:

Professor Gareth Griffiths

TOURIST: Thoracic Umbrella Radiotherapy Study in Stage IV NSCLC

Researchers:

Professor Gareth Griffiths

Professor Lynn Calman

Understanding the variation of modern endoscopic ultrasound use in patients with oesophageal cancer (VALUE): a multi-methods study

Researchers:

Professor Gareth Griffiths

Professor Tim Underwood ,

Professor Andrew Cook ,

Doctor Katherine Bradbury ,

Doctor Sean Ewings

NEOPOLEM: A phase II trial of neoadjuvant PD-1 vaccine PD1-Vaxx in operable MSI high colorectal cancer (CRC).

Researchers:

Professor Gareth Griffiths

Professor Simon Crabb

(PILOT) SAFE-D: Screening of pAncreatic pathology aFtEr Diabetes diagnosis

Researchers:

Professor Gareth Griffiths

Professor Andy Davies ,

Doctor Mark Lown

iDx Lung 2 (Genentech)

Researchers:

Professor Gareth Griffiths

Professor James Batchelor ,

Professor Peter Johnson

An open, prospective Phase III clinical study to compare polatuzumab vedotin plus rituximab, ifosfamide, carboplatin and etoposide (PolaRICE) with rituximab, ifosfamide, carboplatin and etoposide (RICE)

Researchers:

Professor Andy Davies

Professor Gareth Griffiths

STREAM programme

Researchers:

Professor Paul Little

Professor Gareth Griffiths

RECON programme

Researchers:

Professor Paul Little

Professor Lucy Yardley ,

Professor Tony Kendrick ,

Professor Gareth Griffiths

SAFA study (Spironolactone for Adult Female Acne)

Researchers:

Professor Miriam Santer

Professor Paul Little ,

Professor Ingrid Muller ,

Professor Gareth Griffiths ,

Professor Nick Francis

Researchers:

Doctor Adam Geraghty

Professor Lisa Roberts ,

Professor Paul Little ,

Professor Lucy Yardley ,

Professor Gareth Griffiths

Multicentre trial of the clinical and cost effectiveness of a novel urinary catheter designs in preventing catheter-associated urinary tract infection compared with the traditional Foley design for adults requiring long-term urethral catheterisation (CaDE

Researchers:

Professor Cathy Murphy

Doctor Sandra Wilks ,

Professor Andrew Cook ,

Professor Gareth Griffiths ,

Doctor Mark Lown

Acne Care Online

Researchers:

Professor Miriam Santer

Professor Paul Little ,

Professor Lucy Yardley ,

Mrs Jo Kelly ,

Professor Ingrid Muller ,

Doctor Taeko Becque ,

Professor Gareth Griffiths ,

Mrs Sonia Newman ,

Professor Nick Francis ,

Doctor Rosie Essery ,

Doctor Mary Steele ,

Doctor Stephanie Easton ,

Mrs Julie Hooper ,

Doctor Joanna Slodkowska-Barabasz ,

Doctor Sebastien Pollet

Researchers:

Professor Issy Reading

Doctor Sarah Brien ,

Professor Gareth Griffiths

PHASED IN - PHarmacy partnership using decision-making tools and near patient testing for Antimicrobial Stewardship for EveryDay practice IN primary care

Researchers:

Professor Paul Little

Doctor Mark Lown ,

Professor Gareth Griffiths ,

Professor Ingrid Muller ,

Professor Sue Latter ,

Professor Nick Francis ,

Professor Tracey Sach ,

Professor Lucy Yardley ,

Doctor Taeko Becque ,

Doctor Jane Vennik ,

Mrs Samantha Williams ,

Doctor Sascha Miller

Antibiotics for acute LRTI in older people

Researchers:

Doctor Mark Lown

Professor Paul Little ,

Professor Gareth Griffiths ,

Professor Nick Francis ,

Professor Tracey Sach

UNIVERSAL Study (Sanofi)

Researchers:

Professor Tom Wilkinson

Professor Gareth Griffiths

Cost-effective multi-cancer early detection by measuring patient plasma amino acid cross sections with the Enlighten test

Researchers:

Professor Andy Davies

Professor Simon Crabb ,

Mr Sam Wilding ,

Professor Gareth Griffiths ,

Professor Joanne Lord

UH-CAN (LUNG) - Home Urine Collection for Lung Cancer Screening (JM)

Researchers:

Professor Simon Crabb

Professor Gareth Griffiths

Completed projects

Niraparib Efficacy in Relapsed MesOthelioma (NERO). A Randomised Phase II trial of Niraparib versus active symptom control in Patients with Relapsed Malignant Mesothelioma

Researchers:

Professor Gareth Griffiths

Sponsor: British Lung Foundation

Clinical Research Committee, Clinical Trials Unit Programme Award

Researchers:

Professor Gareth Griffiths

Sponsor: Cancer Research UK

LUDWIG - LUD2015-005

Researchers:

Professor Gareth Griffiths

Sponsor: Ludwig Institute for Cancer Research Ltd

Prof Eccles : UoS CTU Core (2) A15956

Researchers:

Professor Gareth Griffiths

Professor Diana Eccles ,

Professor John Primrose ,

Professor Peter Johnson

Sponsor: Cancer Research UK

AGILE: CST 3 Nitazoxanide

Researchers:

Professor Gareth Griffiths

Fractional Flow Reserve Derived from Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain - "FORECAST" - Heartflow Ltd

Researchers:

Professor Gareth Griffiths

Sponsor: Heartflow Inc

G. Griffiths. AGILE: Seamless Phase I/Iia Platform for the Rapid Evaluation of Candidates for COVID-19 treatment

Researchers:

Professor Gareth Griffiths

Sponsor: Wellcome Trust

Griffiths: Energy Trial Marie Curie Lead Uni of Edinburgh Barry Laird

Researchers:

Professor Gareth Griffiths

Sponsor: Marie Curie

A phase II/III randomised study of pembrolizumab in patients with advanced malignant pleural mesothelioma

Researchers:

Professor Gareth Griffiths

Sponsor: Queen's University at Kingston

S Preston - Neo-AEGIS - C49462/A18483

Researchers:

Professor Gareth Griffiths

Sponsor: Cancer Research UK

D FENNELL - CONFIRM - CRUK - A Phase 111 Trial to evaluate the efficacy of Nivolumab

Researchers:

Professor Gareth Griffiths

Sponsor: Cancer Research UK

A DAVIES - A Phase 1b/11 combination of ACP-196 with Rituximiab, Cyclophosphamide, doxorubicin, Vincristine and Prenisolone (R-CHOP) for patients with Diffused B-cell Lymphoma (DLBCL) - "ACCEPT" - ACP-196 - ACERTA

Researchers:

Professor Gareth Griffiths

Sponsor: Acerta Pharma BV

The MENAC Trial - A randomised, open-label trial of a Multimodal Intervention (Exercise, Nutrition and Anti-inflammatory Medication) plus standard care versus standard care alone to prevent / attenuate Cachexia in advanced cancer patients undergoing chemo

Researchers:

Professor Gareth Griffiths

Sponsor: Rising Tide Foundation for Clinical Cancer Research

The MENAC Trial - A Randomised, open-label trial of a Multimodal Intervention (Exercise, Nutrition and Anti - inflammatory Medication) plus standard care versus standard care alone to prevent/ attenuate Cachexia in advanced cancer patients undergoing chem

Researchers:

Professor Gareth Griffiths

Sponsor: Cancer Research UK

SAFE-D: Upfront funding

Researchers:

Professor Gareth Griffiths

Sponsor: ClearNote Health

Tira+Atezo IIS in ctDNA adeno

Researchers:

Professor Gareth Griffiths

Sponsor: F. Hoffmann-La Roche Ltd

Co-designed SCTU trial interventions to increase ethnic diversity in SCTU clinical studies.

Researchers:

Professor Gareth Griffiths

Sponsor: Research England

NIHR Clinical Trials Uni Infrastructure Funding Award

Researchers:

Professor Gareth Griffiths

NIHR CTU Core contract 18-21

Researchers:

Professor Gareth Griffiths

A pragmatic multi-centred randomised controlled trial with economic evaluation, to compare a cycling and educational programme with usual physiotherapy care in the treatment of hip osteoarthritis: CycLing and EducATion (CLEAT).

Researchers:

Professor Gareth Griffiths

S Crabb: Alliance with Plexxikon: A phase Ib/IIa trial to combine the CSF1 receptor inhibitor PLX3397 with the new generation AR antagonist enzalutamide in metastatic castration resistant prostate cancer

Researchers:

Professor Simon Crabb

Professor Gareth Griffiths

Sponsor: Cancer Research UK

A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients

Researchers:

Professor Tom Wilkinson

Professor Robert Read ,

Professor Gareth Griffiths

Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission- Longitudinal (UNIVERSAL) Study (the “Study”)

Researchers:

Professor Tom Wilkinson

Professor Andrew Cook ,

Professor Gareth Griffiths

Sponsor: Janssen Pharmaceuticals Inc.

Molecular Profiling for Lymphoma Study

Researchers:

Professor Peter Johnson

Professor Andy Davies ,

Professor Gareth Griffiths

Sponsor: Blood Cancer UK

S Crabb-Astex Pharmaceuticals Inc - SGI-110-EP10

Researchers:

Professor Simon Crabb

Professor Gareth Griffiths

Sponsor: Astex Pharmaceuticals, Inc.

CTU - Ottensmeier - BioNTech - Hare40

Researchers:

Professor Peter Johnson ,

Professor Gareth Griffiths

Sponsor: BioNTech

Johnson - LLR - 15002 - Precision medicine for aggressive lymphoma

Researchers:

Professor Peter Johnson

Professor Andy Davies ,

Professor Gareth Griffiths

Sponsor: Blood Cancer UK

Sean Lim - RAVE - CRUK (NAC) and Celldex : A phase IIa study of rituximab and varlilumab in relapsed or refractory B-cell malignancies (RAVE study).

Researchers:

Professor Sean Lim

Professor Gareth Griffiths

Sponsor: Cancer Research UK

S Crabb: Alliance with Plexxikon: A phase Ib/IIa trial to combine the CSF1 receptor inhibitor PLX3397 with the new generation AR antagonist enzalutamide in metastatic castration resistant prostate cancer

Researchers:

Professor Simon Crabb

Professor Gareth Griffiths

Sponsor: Plexxikon Inc

Sean Lim - CELLDEX -RAVE - CRUK (NAC) and Celldex : A phase IIa study of rituximab and varlilumab in relapsed or refractory B-cell malignancies (RAVE study).

Researchers:

Professor Sean Lim

Professor Gareth Griffiths

Sponsor: Celldex Therapeutics Inc

Debbie Fenlon, Breast Cancer Now - MENOS4: A multicentre Randomised Controlled Trial (RCT) of a breast care nurse delivered cognitive behavioural therapy (CBT) intervention to reduce the impact of hot flushes in women with breast cancer

Researchers:

Professor Gareth Griffiths

Sponsor: Breast Cancer Now

S Crabb - CRUKD/16/004 SPIRE -C9317/A19903

Researchers:

Professor Simon Crabb

Professor Gareth Griffiths

Sponsor: Cancer Research UK

Dr A Davies - IELSG 42 - CRUK/14/044 - A18805

Researchers:

Professor Peter Johnson ,

Professor Gareth Griffiths

Sponsor: Cancer Research UK

A Davies - G-Gemox A - LOI - Roche Pharmaceuticals - EPBA1877165- G-A46

Researchers:

Professor Gareth Griffiths

Sponsor: F. Hoffmann-La Roche Ltd

Researchers:

Emeritus Professor Michael Moore

Doctor Xiao-Yang (Mio) Hu ,

Doctor Merlin Willcox ,

Professor Paul Little ,

Professor Nick Francis ,

Professor Gareth Griffiths

Prof Eccles: STOPAH

Researchers:

Professor Diana Eccles

Professor Gareth Griffiths

G Griffiths - ROCS - CARDIFF UNIVERSITY - NIHR

Researchers:

Professor Gareth Griffiths

CLASP Cancer: Life Affirming Survivorship support in Primary care

Researchers:

Professor Paul Little

Professor Lucy Yardley ,

Professor Geraldine Leydon ,

Emeritus Professor Michael Moore ,

Doctor Adam Geraghty ,

Professor Claire Foster ,

Professor Alison Richardson ,

Professor Dankmar Böhning ,

Professor Gareth Griffiths

Researchers:

Professor Tony Kendrick

Doctor Judith Joseph ,

Professor Geraldine Leydon ,

Professor Paul Little ,

Emeritus Professor Michael Moore ,

Doctor Adam Geraghty ,

Professor Gareth Griffiths

ECO Eczema Care Online

Researchers:

Professor Miriam Santer

Professor Paul Little ,

Professor Lucy Yardley ,

Professor Ingrid Muller ,

Professor Gareth Griffiths

Researchers:

Professor Tony Kendrick

Emeritus Professor Michael Moore ,

Doctor Adam Geraghty ,

Mrs Samantha Williams ,

Professor Geraldine Leydon ,

Professor Gareth Griffiths

RECUR programme

Researchers:

Professor Paul Little

Professor Lucy Yardley ,

Doctor Adam Geraghty ,

Emeritus Professor Michael Moore ,

Doctor Ben Ainsworth ,

Professor Gareth Griffiths ,

Doctor Jane Vennik

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