Research
Research groups
Research interests
- Chemical Biology
- Medicinal Chemistry
- Protein Sciences
- Cancer
- Orphan and Rare Diseases
Current research
Our research is multidisciplinary and strongly relies on synthetic organic chemistry and biophysical techniques (e.g. DSF/DSC, ITC, NMR spectroscopy), combined with chemical/structural biology and computational methods (e.g. docking, QM). Our primary focus is on the development of chemistry driven approaches to modulate proteins’ physiological activity in a wide sense, with the ultimate goal to deliver new tools to study proteins’ function in living systems. Whenever possible, we exploit the knowledge gained from these studies to attempt tackling difficult problems in human health, notably in cancer, in collaboration with teams of biologists.
Research projects
Completed projects
Publications
Supervision
Current PhD Students
Teaching
Chemical Biology
Medicinal Chemistry
Organic Reactions and Mechanisms
Laboratory Skills
Analytical Chemistry
Biography
Dr Matthias Baud is Associate Professor in Medicinal Chemistry and Chemical Biology at the University of Southampton
Matthias obtained his BSc from the Université de Besançon (France) in 2006 and MSc from the Ecole Polytechnique Fédérale de Lausanne in 2008. He then moved to the UK to undertake PhD studies at Imperial College London under Professor Matthew Fuchter, working on the development of new chemical probes for epigenetics. After obtaining his PhD in 2011, he moved to the University of Cambridge to work with Professor Alessio Ciulli, followed by a short stay at the School of Life Sciences at the University of Dundee. From 2013 to 2016, he held an MRC Career Development Fellowship at the MRC Laboratory of Molecular Biology in Cambridge, to investigate protein reactivation by small molecules in oncology. He joined the School of Chemistry at the University of Southampton in September 2016, and was promoted to Associate Professor in 2022.
Prizes
- Roger Griffin Prize for Cancer Drug Discovery (2016)
- Current strategies for the design of PROTAC linkers: a critical review. (2021)