Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researchers

Professor Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Professor

Research interests

Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Connect with Hans Michael

Email: H.M.Haitchi@soton.ac.uk

Research outputs

Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model

Julie A. Cakebread, Hans Michael Haitchi, Yunhe Xu, Stephen T Holgate, Graham Roberts & Donna E Davies, 2014, PLoS ONE, 9(4), e94010-[7pp]

DOI: 10.1371/journal.pone.0094010

Type: article

Sox17 is required for normal pulmonary vascular morphogenesis.

Alexander W. Lange, Hans Michael Haitchi, Timothy D. LeCras, Anusha Sridharan, Yan Xu, Susan E. Wert, Jeanne James, Nicholas Udell, Philipp J. Thurner & Jeffrey A. Whitsett, 2014, Developmental Biology, 387(1), 109-120

DOI: 10.1016/j.ydbio.2013.11.018

Type: article

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity

Gang Chen, Thomas R. Korfhagen, Christopher L. Karp, Soren Impey, Yan Xu, Scott H. Randell, Joseph Kitzmiller, Yutaka Maeda, Hans Michael Haitchi, Anusha Sridharan, Albert P. Senft & Jeffrey A. Whitsett, 2014, American Journal of Respiratory and Critical Care Medicine, 189(3), 301-313

DOI: 10.1164/rccm.201306-1181OC

Type: article

CaMKII is essential for the proasthmatic effects of oxidation

Philip N. Sanders, Olha M. Koval, Omar A. Jaffer, Anand M. Prasad, Thomas R. Businga, Jason A. Scott, Patrick J. Hayden, Elizabeth D. Luczak, David D. Dickey, Chantal Allamargot, Alicia K. Olivier, David K. Meyerholz, Alfred J. Robison, Danny G. Winder, Timothy S. Blackwell, Ryszard Dworski, David Sammut, Brett A. Wagner, Garry R. Buettner, Robert M. Pope, Francis J. Miller, Megan E. Dibbern, Hans Michael Haitchi, Peter J. Mohler, Peter H. Howarth, Joseph Zabner, Joel N. Kline, Isabella M. Grumbach & Mark E. Anderson, 2013, Science Translational Medicine, 5(195), 195ra97

DOI: 10.1126/scitranslmed.3006135

Type: article

ADAM33

Hans Michael Haitchi & Donna E. Davies, 2012

DOI: 10.1016/B978-0-12-382219-2.00257-X

Type: bookChapter

Resistin‐like molecule‐β is induced following bronchoconstriction of asthmatic airways

Christopher L. Grainge, Valdeep Dulay, Jonathan Ward, David Sammut, Elizabeth Davies, Benjamin Green, Laurie C.K. Lau, Laura Cottey, Hans-Michael Haitchi, Donna E. Davies & Peter H. Howarth, 2012, Respirology, 17(7), 1094-1100

DOI: 10.1111/j.1440-1843.2012.02215.x

Type: article

SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia

T.R. Korfhagen, J. Kitzmiller, G. Chen, A. Sridharan, H.M. Haitchi, R.S. Hegde, S. Divanovic, C.L. Karp & J.A. Whitsett, 2012, Proceedings of the National Academy of Sciences, 109(41), 16630-16635

DOI: 10.1073/pnas.1208092109

Type: article