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Research project

Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researcher

Dr Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Associate Professor

Research interests

  • Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
  • Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
  • Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Research outputs

Soluble adam33 augments the pulmonary immune response promoting allergic airway sensitivity
Joanne, Freda Carmichael Kelly,
Elizabeth Davies,
Stephen Holgate,
X Xu,
J.A. Whitsett,
Donna Davies,
& Hans Haitchi
, 2017
DOI: 10.1136/thoraxjnl-2017-210983.95
Type: conference
Increased expression of p22phox mediates airway hyperresponsiveness in an experimental model of asthma
Chandran Nagaraj,
Hans Michael Haitchi,
Akos Heinemann,
Peter Howarth,
Andrea Olschewski,
& Leigh M Marsh
, 2017 , Antioxidants & Redox Signaling , 27 (18) , 1460--1472
DOI: 10.1089/ars.2016.6863
Type: article
Locked Nucleic Acid gapmers and conjugates induce potent silencing of ADAM33, an asthma-associated metalloprotease with nuclear-localized mRNA
Hannah M Pendergraff,
Pranathi Meda Krishnamurthy,
Alexandre J. Debacker,
Michael Moazami,
Vivek K. Sharma,
Liisa Niitsoo,
Yong Yu,
Yen Nee Tan,
Hans Michael Haitchi,
& Jonathan K. Watts
, 2017 , Molecular Therapy: Nucleic Acid
DOI: 10.1016/j.omtn.2017.06.012
Type: article
Corticosteroid-resistant neutrophilic airway inflammation and hyperresponsiveness caused by il-13
Elizabeth Davies,
Joanne, Freda Carmichael Kelly,
J.A. Whitsett,
Stephen Holgate,
Donna Davies,
& Hans Haitchi
, 2017
DOI: 10.1136/thoraxjnl-2017-210983.91
Type: conference
Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life
Elizabeth R. Davies,
Joanne F. Kelly,
Peter H. Howarth,
David Wilson,
Stephen Holgate,
Donna E. Davies,
Jeffrey A. Whitsett,
& Hans Michael Haitchi
, 2016 , JCI Insight , 1 (11) , 1--16
DOI: 10.1172/jci.insight.87632
Type: article