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Research project

Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researcher

Dr Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Associate Professor

Research interests

  • Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
  • Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
  • Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Research outputs

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients
Julia Hoffmann,
Leigh M. Marsh,
Mario Pieper,
Elvira Stacher,
Bahil Ghanim,
Gabor Kovacs,
Peter König,
Heinrike Wilkens,
Hans Michael Haitchi,
Gerald Hoefler,
Walter Klepetko,
Horst Olschewski,
Andrea Olschewski,
& Grazyna Kwapiszewska
, 2015 , American Journal of Physiology: Lung Cellular and Molecular Physiology , 308 (10) , L1002--L1013
DOI: 10.1152/ajplung.00383.2014
Type: article
Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity
Gang Chen,
Thomas R. Korfhagen,
Christopher L. Karp,
Soren Impey,
Yan Xu,
Scott H. Randell,
Joseph Kitzmiller,
Yutaka Maeda,
Hans Michael Haitchi,
Anusha Sridharan,
Albert P. Senft,
& Jeffrey A. Whitsett
, 2014 , American Journal of Respiratory and Critical Care Medicine , 189 (3) , 301--313
DOI: 10.1164/rccm.201306-1181OC
Type: article
Sox17 is required for normal pulmonary vascular morphogenesis.
Alexander W. Lange,
Hans Michael Haitchi,
Timothy D. LeCras,
Anusha Sridharan,
Yan Xu,
Susan E. Wert,
Jeanne James,
Nicholas Udell,
Philipp J. Thurner,
& Jeffrey A. Whitsett
, 2014 , Developmental Biology , 387 (1) , 109--120
DOI: 10.1016/j.ydbio.2013.11.018
Type: article
Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model
Julie A. Cakebread,
Hans Michael Haitchi,
Yunhe Xu,
Stephen T Holgate,
Graham Roberts,
& Donna E Davies
, 2014 , PLoS ONE , 9 (4) , e94010--[7pp]
DOI: 10.1371/journal.pone.0094010
Type: article
CaMKII is essential for the proasthmatic effects of oxidation
Philip N. Sanders,
Olha M. Koval,
Omar A. Jaffer,
Anand M. Prasad,
Thomas R. Businga,
Jason A. Scott,
Patrick J. Hayden,
Elizabeth D. Luczak,
David D. Dickey,
Chantal Allamargot,
Alicia K. Olivier,
David K. Meyerholz,
Alfred J. Robison,
Danny G. Winder,
Timothy S. Blackwell,
Ryszard Dworski,
David Sammut,
Brett A. Wagner,
Garry R. Buettner,
Robert M. Pope,
Francis J. Miller,
Megan E. Dibbern,
Hans Michael Haitchi,
Peter J. Mohler,
Peter H. Howarth,
Joseph Zabner,
Joel N. Kline,
Isabella M. Grumbach,
& Mark E. Anderson
, 2013 , Science Translational Medicine , 5 (195) , 195ra97
DOI: 10.1126/scitranslmed.3006135
Type: article