Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researchers

Professor Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Professor

Research interests

Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Connect with Hans Michael

Email: H.M.Haitchi@soton.ac.uk

Research outputs

Clinical evaluation of type 2 disease status in a real-world population of difficult to manage asthma using historic Electronic Health Care Records of Blood Eosinophil counts

Adnan Azim, Colin Newell, Clair Barber, Matthew Harvey, Deborah Knight, Anna Freeman, Wei Chern Gavin Fong, Paddy Dennison, Hans Michael Haitchi, Ratko Djukanovic, Ramesh Kurukulaaratchy & Peter Howarth, 2021, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 51(6), 811-820

DOI: 10.1111/cea.13841

Type: article

New perspectives on difficult asthma; sex and age of asthma-onset based phenotypes

Adnan Azim, Anna Freeman, Audrey Lavenu, Heena Mistry, Hans Michael Haitchi, Colin Newell, Yueqing Cheng, Yvette Thirlwall, Matthew Harvey, Clair Barber, Katarina Pontoppidan, Paddy Dennison, S. Hasan Arshad, Ratko Djukanovic, Peter Howarth & Ramesh J. Kurukulaaratchy, 2020, The Journal of Allergy and Clinical immunology: In Practice, 8(10), 3396-3406.e4

DOI: 10.1016/j.jaip.2020.05.053

Type: article

Patient perceived barriers to exercise and their clinical associations in difficult asthma

Anna T Freeman, David Hill, Colin Newell, Helen Moyses, Adnan Azim, Deborah Knight, Laura Presland, Matthew Harvey, Hans Michael Haitchi, Alastair Watson, Karl J Staples, Ramesh J Kurukulaaratchy & Tom M A Wilkinson, 2020, Asthma Research and Practice, 6, 5

DOI: 10.1186/s40733-020-00058-6

Type: article

Involvement of the epidermal growth factor receptor in IL-13 mediated, corticosteroid-resistant airway inflammation

Elizabeth R. Davies, Jeanne Marie Perotin, Joanne Kelly, Ratko Djukanovic, Donna E. Davies & Hans Michael Haitchi, 2020, Clinical & Experimental Allergy, 50(6), 672-686

DOI: 10.1111/cea.13591

Type: article

Airway hyperresponsiveness in offspring from mothers with allergic airway inflammation during pregnancy is muscarinic receptor and ADAM33 dependent

Marieke Wandel, Elizabeth Rhiannon Davies, Joanne Freda Carmichael Kelly, Stephen Holgate, Donna Davies & Hans Haitchi, 2020

DOI: 10.1183/13993003.congress-2020.614

Type: conference

Maternal allergic airway inflammation during pregnancy alters offspring’s airway hyperresponsiveness dependent on muscarinic receptor and adam33 mediated mechanisms

Marieke Wandel, Elizabeth Rhiannon Davies, Joanne Freda Carmichael Kelly, Stephen Holgate, Jeffrey A. Whitsett, Donna Davies & Hans Haitchi, 2019

DOI: 10.1136/thorax-2019-BTSabstracts2019.136

Type: conference

Regulation of Ectodomain shedding of ADAM33 in vitro and in vivo

Elizabeth R. Davies, Laura Denney, Marieke Wandel, Clare M. Lloyd, Donna E. Davies & Hans Michael Haitchi, 2019, Journal of Allergy and Clinical Immunology, 143(6), 2281-2284.e3

DOI: 10.1016/j.jaci.2019.01.026

Type: letterEditorial