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Research project

Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researcher

Dr Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Associate Professor

Research interests

  • Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
  • Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
  • Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Research outputs

Asthma did not increase in-hospital Covid-19 related mortality in a tertiary UK hospital
Wei Chern Gavin Fong,
Florina Borca,
Hang Phan,
Helen E Moyses,
Paddy Dennison,
Ramesh J Kurukulaaratchy,
& Hans Michael Haitchi
, 2021 , Clinical & Experimental Allergy , 51 (7) , 939--941
DOI: 10.1111/cea.13855
Type: letterEditorial
Clinical evaluation of type 2 disease status in a real-world population of difficult to manage asthma using historic Electronic Health Care Records of Blood Eosinophil counts
Adnan Azim,
Colin Newell,
Clair Barber,
Matthew Harvey,
Deborah Knight,
Anna Freeman,
Wei Chern Gavin Fong,
Paddy Dennison,
Hans Michael Haitchi,
Ratko Djukanovic,
Ramesh Kurukulaaratchy,
& Peter Howarth
, 2021 , Clinical & Experimental Allergy , 51 (6) , 811--820
DOI: 10.1111/cea.13841
Type: article
The clinical implications of Aspergillus Fumigatus sensitization in difficult-to-treat asthma patients
Heena Mistry,
Hilda Maria Ajsivinac Soberanis,
Mohammad Aref Kyyaly,
Adnan Azim,
Clair Barber,
Deborah Knight,
Colin Newell,
Hans Michael Haitchi,
Tom Wilkinson,
Peter Howarth,
Grégory Seumois,
Pandurangan Vijayanand,
S Hasan Arshad,
& Ramesh J Kurukulaaratchy
, 2021 , Journal of Allergy and Clinical Immunology: In Practice , 9 (12) , 4254--4267.e10
DOI: 10.1016/j.jaip.2021.08.038
Type: article
Airway hyperresponsiveness in offspring from mothers with allergic airway inflammation during pregnancy is muscarinic receptor and ADAM33 dependent
Marieke Wandel,
Elizabeth Rhiannon Davies,
Joanne Freda Carmichael Kelly,
Stephen Holgate,
Donna Davies,
& Hans Haitchi
, 2020
DOI: 10.1183/13993003.congress-2020.614
Type: conference
Involvement of the epidermal growth factor receptor in IL-13 mediated, corticosteroid-resistant airway inflammation
Elizabeth R. Davies,
Jeanne Marie Perotin,
Joanne Kelly,
Ratko Djukanovic,
Donna E. Davies,
& Hans Michael Haitchi
, 2020 , Clinical & Experimental Allergy , 50 (6) , 672--686
DOI: 10.1111/cea.13591
Type: article