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Research project

Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researcher

Dr Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Associate Professor

Research interests

  • Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
  • Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
  • Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Research outputs

New perspectives on difficult asthma; sex and age of asthma-onset based phenotypes
Adnan Azim,
Anna Freeman,
Audrey Lavenu,
Heena Mistry,
Hans Michael Haitchi,
Colin Newell,
Yueqing Cheng,
Yvette Thirlwall,
Matthew Harvey,
Clair Barber,
Katarina Pontoppidan,
Paddy Dennison,
S. Hasan Arshad,
Ratko Djukanovic,
Peter Howarth,
& Ramesh J. Kurukulaaratchy
, 2020 , Journal of Allergy and Clinical Immunology: In Practice , 8 (10) , 3396--3406.e4
DOI: 10.1016/j.jaip.2020.05.053
Type: article
Patient perceived barriers to exercise and their clinical associations in difficult asthma
Anna T Freeman,
David Hill,
Colin Newell,
Helen Moyses,
Adnan Azim,
Deborah Knight,
Laura Presland,
Matthew Harvey,
Hans Michael Haitchi,
Alastair Watson,
Karl J Staples,
Ramesh J Kurukulaaratchy,
& Tom M A Wilkinson
, 2020 , Asthma Research and Practice , 6 , 5
DOI: 10.1186/s40733-020-00058-6
Type: article
Maternal allergic airway inflammation during pregnancy alters offspring’s airway hyperresponsiveness dependent on muscarinic receptor and adam33 mediated mechanisms
Marieke Wandel,
Elizabeth Rhiannon Davies,
Joanne Freda Carmichael Kelly,
Stephen Holgate,
Jeffrey A. Whitsett,
Donna Davies,
& Hans Haitchi
, 2019
DOI: 10.1136/thorax-2019-BTSabstracts2019.136
Type: conference
Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH)
Adnan Azim,
Heena Mistry,
Anna Freeman,
Clair Barber,
Colin Newell,
Kerry Gove,
Yvette Thirlwall,
Matt Harvey,
Kimberley Bentley,
Deborah Knight,
Karen Long,
Frances Mitchell,
Yueqing Cheng,
Judit Varkonyi-Sepp,
Wolfgang Grabau,
Paddy Dennison,
Hans Michael Haitchi,
S Hasan Arshad,
Ratko Djukanovic,
Tom Wilkinson,
Peter Howarth,
& Ramesh J Kurukulaaratchy
, 2019 , BMC Pulmonary Medicine , 19
DOI: 10.1186/s12890-019-0862-2
Type: article
Regulation of Ectodomain shedding of ADAM33 in vitro and in vivo
Elizabeth R. Davies,
Laura Denney,
Marieke Wandel,
Clare M. Lloyd,
Donna E. Davies,
& Hans Michael Haitchi
, 2019 , Journal of Allergy and Clinical Immunology , 143 (6) , 2281--2284.e3
DOI: 10.1016/j.jaci.2019.01.026
Type: letterEditorial