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Doctor Matthew Blunt

Doctor Matthew Blunt

Senior Research Fellow

Accepting applications from PhD students.

Connect with Matthew


Address: Southampton General Hospital, Tremona Road Shirley, SO16 6YD (View in Google Maps)


Dr Matthew Blunt is a Senior Research Fellow within the Faculty of Medicine and is Assessment Lead for MSc Genomics. He leads a research team focused on natural killer (NK) cells, novel cancer immunotherapies and haematological malignancies.

Examples of published research include:

  • KIR2DS2 expression identifies NK cells with enhanced anti-cancer activity (Blunt MD et al, Journal of Immunology, 2022)
  • XPO1 inhibition stimulates NK cell activation against lymphoma cells (Fisher JG et al, Frontiers in Oncology, 2021).
  • Development of a novel therapeutic to activate NK cells against cancer (Rettman P, Blunt MD et al, Journal for immunotherapy of cancer, 2021).
  • Targeting the PI3K/mTOR pathway in CLL (Blunt MD et al, Blood, 2015).
  • Identification of IL-4 as a resistance mechanism to idelalisib and ibrutinib (Aguilar-Hernandez M, Blunt MD et al, Blood, 2016 *Co-first author).
  • Preclinical evaluation of the dual SYK/JAK inhibitor cerdulatinib alone and in combination with venetoclax (Blunt MD et al, Clinical Cancer Research, 2016).
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