Research project

Targeting natural killer cell receptors for immunotherapeutic benefit

Lead researchers:

Professor Salim Khakoo
Other researchers:

Dr Ali Roghanian
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researchers

Professor Salim Khakoo

Professor of Hepatology

Connect with Salim

Email: S.I.Khakoo@soton.ac.uk

Other researchers

Dr Ali Roghanian PhD, FHEA

Associate Professor

Research interests

Cancer immunotherapy
Monoclonal antibodies
Cellular therapies (e.g., CAR T and iNKT cells)

Connect with Ali

Email: A.Roghanian@soton.ac.uk

Research outputs

KIR2DS2 expression identifies NK cells with enhanced anticancer activity

Matthew Blunt, Mark Cragg, Amber Doyle, Jack, Graham Fisher, Salim Khakoo, Francesco Forconi, Peter Johnson, Marta Ewa Polak, Lara, Victoria Graham, Andres Vallejo Pulido, Rebecca Fulton & Matthew Carter, 2022, The Journal of Immunology, 209 (2)(2), 379-390

DOI: 10.4049/jimmunol.2101139

Type: article

Trans-ancestral fine-mapping of MHC reveals key amino acids associated with spontaneous clearance of hepatitis C in HLA-DQ beta 1

Ana Valencia, Candelaria Vergara, Chloe L Thio, Nicolas Vince, Venceslas Douillard, Alba Grifoni, Andrea L Cox, Eric O Johnson, Alex H Kral, James J Goedert, Alessandra Mangia, Valeria Piazzolla, Shruti H Mehta, Gregory D Kirk, Arthur Y Kim, Georg M Lauer, Raymond T Chung, Jennifer C Price, Salim I Khakoo, Laurent Alric, Matthew E Cramp, Sharyne M Donfield, Brian R Edlin, Michael P Busch, Graeme Alexander, Hugo R Rosen, Edward L Murphy, Genevieve L Wojcik, Mary Carrington, Pierre-Antoine Gourraud, Alessandro Sette, David L Thomas & Priya Duggal, 2022, American Journal of Human Genetics, 109(2), 299-310

DOI: 10.1016/j.ajhg.2022.01.001

Type: article

Selinexor enhances NK cell activation against malignant B cells via downregulation of HLA-E

Jack, Graham Fisher, Salim Khakoo, Mark Cragg, Francesco Forconi, Peter Johnson, Amber Doyle, christopher Walker, yosef landesman & Matthew Blunt, 2021, Frontiers in Oncology

DOI: 10.3389/fonc.2021.785635

Type: article

The role of NK cells in oncolytic viral therapy

Frazer Warricker, Salim I. Khakoo & Matthew D. Blunt, 2021, Journal of Translational Genetics and Genomics, 5, 304-322

DOI: 10.20517/jtgg.2021.27

Type: article

A peptide: MHC based DNA vaccination strategy to activate natural killer cells by targeting killer cell immunoglobulin-like receptors.

Salim Khakoo, Pauline E Rettman, Matthew Blunt, Rebecca Fulton, Andres Vallejo Pulido, Leidy Bastidas Legarda, Laura Espana-Serrano, Marta Polak, Aymen Al-Shamkhani & Christelle Retiere, 2021, Journal for Immunotherapy of Cancer, 9(5)

DOI: 10.1136/jitc-2020-001912

Type: article