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Professor Aymen Al-Shamkhani

Professor Aymen Al-Shamkhani

Professor in Immunology

Research interests

  • Cancer Immunotherapy
  • Immunobiology of costimulatory receptors
  • Immunostimulatory antibodies

More research

Accepting applications from PhD students.

Connect with Aymen

Email: a.al-shamkhani@soton.ac.uk

Address: Southampton General Hospital, Tremona Road Shirley, SO16 6YD (View in Google Maps)

Research

Research groups

Member of:

Research interests

  • Cancer Immunotherapy
  • Immunobiology of costimulatory receptors
  • Immunostimulatory antibodies
  • Cytotoxic and memory CD8 T cells
  • Mechanisms of tumour immune evasion and resistance to immunotherapy

Current research

Professor Al-Shamkhani’s team is investigating receptors and signalling pathways that regulate T cell responses with a focus on developing strategies that promote anti-tumour immunity. Key areas of interest in his laboratory concern the immunobiology of costimulatory receptors as well as the development of antibody therapies that target these receptors. His group is also investigating potential signalling pathways that are important in effector and memory CD8 T cell differentiation. In addition to fundamental studies on T cell activation, there are ongoing studies on the characterisation of immune responses in human solid cancers. These studies aim to define the major factors that drive immune evasion as well as resistance to immunotherapy.

Research projects

Active projects

Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Cancer Research UK

Completed projects

Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Tenovus
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Cancer Research UK
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Blood Cancer UK
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Blood Cancer UK
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Worldwide Cancer Research
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Tenovus
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Blood Cancer UK
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Wellcome Trust
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Cancer Research UK
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: Worldwide Cancer Research
Researchers:
Professor Aymen Al-Shamkhani
Sponsor: BLINK BIOMEDICAL SAS
Researchers: ,
Professor Aymen Al-Shamkhani
Sponsor: Bowel Disease Research Foundation
Researchers: ,
Professor Aymen Al-Shamkhani
Sponsor: British Liver Trust
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